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Zinc in PDB 3d06: Human P53 Core Domain with Hot Spot Mutation R249S (I)

Protein crystallography data

The structure of Human P53 Core Domain with Hot Spot Mutation R249S (I), PDB code: 3d06 was solved by H.Rozenberg, O.Suad, L.J.W.Shimon, F.Frolow, Z.Shakked, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 17.34 / 1.20
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 44.157, 44.157, 329.369, 90.00, 90.00, 120.00
R / Rfree (%) 17.6 / 20.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Human P53 Core Domain with Hot Spot Mutation R249S (I) (pdb code 3d06). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human P53 Core Domain with Hot Spot Mutation R249S (I), PDB code: 3d06:

Zinc binding site 1 out of 1 in 3d06

Go back to Zinc Binding Sites List in 3d06
Zinc binding site 1 out of 1 in the Human P53 Core Domain with Hot Spot Mutation R249S (I)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human P53 Core Domain with Hot Spot Mutation R249S (I) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1

b:15.3
occ:1.00
ND1 A:HIS179 2.0 18.7 1.0
SG A:CYS242 2.3 15.8 1.0
SG A:CYS176 2.3 15.9 1.0
SG A:CYS238 2.3 15.6 0.5
SG A:CYS238 2.3 16.3 0.5
CE1 A:HIS179 2.9 20.6 1.0
CG A:HIS179 3.0 20.3 1.0
CB A:CYS242 3.1 18.8 1.0
CB A:CYS238 3.4 15.3 0.5
CB A:CYS176 3.4 17.1 1.0
CB A:HIS179 3.5 21.3 1.0
CB A:CYS238 3.7 22.9 0.5
CA A:CYS238 3.9 14.1 0.5
CA A:CYS238 3.9 18.0 0.5
N A:CYS176 4.0 16.0 1.0
NE2 A:HIS179 4.0 22.9 1.0
CD2 A:HIS179 4.1 24.7 1.0
N A:ASN239 4.3 17.1 1.0
CA A:CYS176 4.3 16.6 1.0
N A:HIS179 4.5 20.2 1.0
CA A:CYS242 4.5 19.3 1.0
C A:CYS238 4.6 16.1 1.0
O A:HOH332 4.6 23.4 1.0
CA A:HIS179 4.6 20.4 1.0
O A:HOH377 4.9 20.6 0.5
O A:MET237 4.9 20.1 1.0
C A:CYS176 5.0 17.2 1.0
O A:CYS176 5.0 17.6 1.0

Reference:

O.Suad, H.Rozenberg, R.Brosh, Y.Diskin-Posner, N.Kessler, L.J.W.Shimon, F.Frolow, A.Liran, V.Rotter, Z.Shakked. Structural Basis of Restoring Sequence-Specific Dna Binding and Transactivation to Mutant P53 By Suppressor Mutations J.Mol.Biol. V. 385 249 2009.
ISSN: ISSN 0022-2836
PubMed: 18996393
DOI: 10.1016/J.JMB.2008.10.063
Page generated: Wed Dec 16 04:11:43 2020

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