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Atomistry » Zinc » PDB 2y7e-2yql » 2ypu | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 2y7e-2yql » 2ypu » |
Zinc in PDB 2ypu: Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367Enzymatic activity of Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367
All present enzymatic activity of Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367:
3.4.24.56; Protein crystallography data
The structure of Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367, PDB code: 2ypu
was solved by
Q.Guo,
R.Deprez-Poulain,
B.Deprez,
W.-J.Tang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367
(pdb code 2ypu). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367, PDB code: 2ypu: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 2ypuGo back to Zinc Binding Sites List in 2ypu
Zinc binding site 1 out
of 2 in the Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 2ypuGo back to Zinc Binding Sites List in 2ypu
Zinc binding site 2 out
of 2 in the Human Insulin Degrading Enzyme E111Q in Complex with Inhibitor Compound 41367
Mono view Stereo pair view
Reference:
J.Charton,
M.Gauriot,
Q.Guo,
N.Hennuyer,
X.Marechal,
J.Dumont,
M.Hamdane,
V.Pottiez,
V.Landry,
O.Sperandio,
M.Flipo,
L.Buee,
B.Staels,
F.Leroux,
W.-J.Tang,
B.Deprez,
R.Deprez-Poulain.
Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis Eur J Med Chem V. 79C 184 2014.
Page generated: Wed Dec 16 04:02:27 2020
ISSN: ISSN 0223-5234 PubMed: 24735644 DOI: 10.1016/J.EJMECH.2014.04.009 |
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