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Zinc in PDB 2yhw: High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling.

Enzymatic activity of High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling.

All present enzymatic activity of High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling.:
2.7.1.60;

Protein crystallography data

The structure of High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling., PDB code: 2yhw was solved by J.Martinez, L.D.Nguyen, E.Tauberger, S.Hinderlich, R.Zimmer, E.Tauberger, W.Reutter, W.Saenger, H.Fan, S.Moniot, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.37 / 1.64
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 90.730, 90.730, 100.780, 90.00, 90.00, 90.00
R / Rfree (%) 14.82 / 17.019

Other elements in 2yhw:

The structure of High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling. also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling. (pdb code 2yhw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling., PDB code: 2yhw:

Zinc binding site 1 out of 1 in 2yhw

Go back to Zinc Binding Sites List in 2yhw
Zinc binding site 1 out of 1 in the High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of High-Resolution Crystal Structures of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity and Inhibitor Modelling. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1719

b:14.2
occ:1.00
 ND1 A:HIS569 2.1 13.0 1.0
SG A:CYS586 2.3 14.5 1.0
SG A:CYS581 2.3 14.0 1.0
SG A:CYS579 2.4 15.2 1.0
CE1 A:HIS569 2.9 12.7 1.0
CB A:CYS579 3.1 15.9 1.0
CB A:CYS586 3.1 14.1 1.0
CG A:HIS569 3.2 11.8 1.0
CB A:CYS581 3.3 14.2 1.0
CB A:HIS569 3.7 12.1 1.0
CA A:HIS569 4.1 12.5 1.0
NE2 A:HIS569 4.1 12.4 1.0
CD2 A:HIS569 4.2 13.5 1.0
N A:CYS581 4.3 14.5 1.0
CA A:CYS581 4.4 13.9 1.0
CB A:SER583 4.4 18.8 1.0
O A:HOH2166 4.5 16.5 1.0
O A:GLY568 4.5 12.2 1.0
CA A:CYS579 4.6 15.4 1.0
CA A:CYS586 4.6 13.6 1.0
N A:HIS569 4.9 13.5 1.0
C A:CYS579 5.0 15.0 1.0
N A:SER583 5.0 15.6 1.0

Reference:

J.Martinez, L.D.Nguyen, E.Tauberger, S.Hinderlich, W.Reutter, H.Fan, W.Saenger, S.Moniot. Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition J.Biol.Chem. V. 287 13656 2012.
ISSN: ISSN 0021-9258
PubMed: 22343627
DOI: 10.1074/JBC.M111.318170
Page generated: Thu Oct 17 05:50:24 2024

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