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Zinc in PDB 2w5y: Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine.

Enzymatic activity of Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine.

All present enzymatic activity of Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine.:
2.1.1.43;

Protein crystallography data

The structure of Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine., PDB code: 2w5y was solved by S.M.Southall, P.S.Wong, Z.Odho, S.M.Roe, J.R.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.66 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.850, 56.210, 78.240, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 26.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine. (pdb code 2w5y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine., PDB code: 2w5y:

Zinc binding site 1 out of 1 in 2w5y

Go back to Zinc Binding Sites List in 2w5y
Zinc binding site 1 out of 1 in the Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Binary Complex of the Mixed Lineage Leukaemia (MLL1) Set Domain with the Cofactor Product S-Adenosylhomocysteine. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn4970

b:47.7
occ:1.00
 SG A:CYS3957 2.3 42.7 1.0
SG A:CYS3959 2.4 46.1 1.0
SG A:CYS3909 2.5 47.8 1.0
SG A:CYS3964 2.7 53.0 1.0
CB A:CYS3909 3.4 46.5 1.0
CB A:CYS3957 3.5 50.1 1.0
CB A:CYS3959 3.5 44.0 1.0
CB A:CYS3964 3.5 54.1 1.0
CA A:CYS3964 3.8 57.0 1.0
N A:CYS3909 3.8 39.1 1.0
N A:ARG3965 3.9 57.6 1.0
N A:CYS3959 4.1 44.3 1.0
CA A:CYS3909 4.2 36.3 1.0
CA A:CYS3959 4.3 43.7 1.0
C A:CYS3964 4.3 60.1 1.0
NE2 A:HIS3907 4.4 37.5 1.0
O A:HOH2129 4.4 46.3 1.0
CD2 A:HIS3907 4.5 35.0 1.0
N A:LYS3966 4.5 62.3 1.0
CB A:ALA3961 4.6 57.4 1.0
O A:CYS3959 4.7 52.0 1.0
C A:CYS3957 4.7 48.2 1.0
CA A:CYS3957 4.7 49.0 1.0
C A:CYS3959 4.7 46.8 1.0
O A:CYS3957 4.7 51.1 1.0
C A:SER3908 4.8 36.2 1.0
CA A:ARG3965 5.0 59.7 1.0
CA A:SER3908 5.0 34.1 1.0

Reference:

S.M.Southall, P.S.Wong, Z.Odho, S.M.Roe, J.R.Wilson. Structural Basis For the Requirement of Additional Factors For MLL1 Set Domain Activity and Recognition of Epigenetic Marks. Mol.Cell V. 33 181 2009.
ISSN: ISSN 1097-2765
PubMed: 19187761
DOI: 10.1016/J.MOLCEL.2008.12.029
Page generated: Thu Oct 17 04:45:44 2024

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