Zinc in PDB 2srt: Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor

All present enzymatic activity of Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor:
3.4.24.17;

The binding sites of Zinc atom in the Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor (pdb code 2srt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor, PDB code: 2srt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn257 b:0.0 occ:1.00 O4 A:INH256 2.1 0.0 1.0 NE2 A:HIS201 2.1 0.0 1.0 NE2 A:HIS211 2.2 0.0 1.0 NE2 A:HIS205 2.2 0.0 1.0 CD2 A:HIS211 2.7 0.0 1.0 HD2 A:HIS211 2.8 0.0 1.0 CE1 A:HIS201 3.0 0.0 1.0 CD2 A:HIS201 3.1 0.0 1.0 C3 A:INH256 3.1 0.0 1.0 CE1 A:HIS205 3.2 0.0 1.0 CD2 A:HIS205 3.2 0.0 1.0 HE1 A:HIS201 3.2 0.0 1.0 CE1 A:HIS211 3.3 0.0 1.0 HE1 A:HIS205 3.3 0.0 1.0 HD2 A:HIS201 3.4 0.0 1.0 H70 A:INH256 3.4 0.0 1.0 HD2 A:HIS205 3.5 0.0 1.0 H39 A:INH256 3.7 0.0 1.0 HE1 A:HIS211 3.8 0.0 1.0 C2 A:INH256 3.8 0.0 1.0 CG A:HIS211 3.9 0.0 1.0 H41 A:INH256 4.0 0.0 1.0 O5 A:INH256 4.1 0.0 1.0 N6 A:INH256 4.1 0.0 1.0 ND1 A:HIS211 4.2 0.0 1.0 ND1 A:HIS201 4.2 0.0 1.0 CG A:HIS201 4.3 0.0 1.0 ND1 A:HIS205 4.3 0.0 1.0 CG A:HIS205 4.3 0.0 1.0 HE2 A:MET219 4.4 0.0 1.0 H A:HIS211 4.4 0.0 1.0 C7 A:INH256 4.6 0.0 1.0 O A:MET219 4.7 0.0 1.0 H43 A:INH256 4.8 0.0 1.0 HE3 A:MET219 4.9 0.0 1.0 HA A:PRO221 4.9 0.0 1.0 H40 A:INH256 5.0 0.0 1.0 N A:HIS211 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Catalytic Domain of Human Stromelysin-1 at pH 5.5 and 40OC Complexed with Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn258 b:0.0 occ:1.00 NE2 A:HIS151 2.0 0.0 1.0 NE2 A:HIS166 2.2 0.0 1.0 ND1 A:HIS179 2.2 0.0 1.0 CE2 A:TYR155 2.7 0.0 1.0 CE1 A:HIS166 2.7 0.0 1.0 CZ A:TYR155 2.8 0.0 1.0 HE1 A:HIS166 2.9 0.0 1.0 HE2 A:TYR155 3.0 0.0 1.0 CD2 A:HIS151 3.0 0.0 1.0 HB2 A:HIS179 3.0 0.0 1.0 CE1 A:HIS151 3.0 0.0 1.0 CD2 A:TYR155 3.0 0.0 1.0 CD2 A:HIS166 3.1 0.0 1.0 CE1 A:HIS179 3.2 0.0 1.0 HD2 A:HIS151 3.2 0.0 1.0 CG A:HIS179 3.3 0.0 1.0 HE1 A:HIS151 3.3 0.0 1.0 CE1 A:TYR155 3.3 0.0 1.0 HE1 A:HIS179 3.3 0.0 1.0 OH A:TYR155 3.4 0.0 1.0 CG A:TYR155 3.5 0.0 1.0 HE1 A:TYR168 3.5 0.0 1.0 HD2 A:TYR155 3.6 0.0 1.0 CB A:HIS179 3.6 0.0 1.0 CD1 A:TYR155 3.6 0.0 1.0 HD2 A:HIS166 3.6 0.0 1.0 ND1 A:HIS166 3.7 0.0 1.0 CG A:HIS166 4.0 0.0 1.0 HE1 A:TYR155 4.0 0.0 1.0 HB3 A:HIS179 4.0 0.0 1.0 HH A:TYR155 4.0 0.0 1.0 ND1 A:HIS151 4.1 0.0 1.0 CG A:HIS151 4.2 0.0 1.0 HE2 A:PHE157 4.3 0.0 1.0 NE2 A:HIS179 4.3 0.0 1.0 CD2 A:HIS179 4.4 0.0 1.0 HB2 A:TYR155 4.4 0.0 1.0 HD1 A:TYR155 4.4 0.0 1.0 HD1 A:HIS166 4.5 0.0 1.0 CE1 A:TYR168 4.5 0.0 1.0 CB A:TYR155 4.6 0.0 1.0 HD12 A:ILE174 4.7 0.0 1.0 H A:HIS179 4.8 0.0 1.0 O A:TYR155 4.9 0.0 1.0 CA A:HIS179 5.0 0.0 1.0 HD2 A:PHE157 5.0 0.0 1.0

P.R.Gooley, J.F.O'connell, A.I.Marcy, G.C.Cuca, S.P.Salowe, B.L.Bush, J.D.Hermes, C.K.Esser, W.K.Hagmann, J.P.Springer, B.A.Johnson. The uc(Nmr) Structure of the Inhibited Catalytic Domain of Human Stromelysin-1. Nat.Struct.Biol. V. 1 111 1994.
ISSN: ISSN 1072-8368
PubMed: 7656014
DOI: 10.1038/NSB0294-111