Zinc in PDB 2poj: uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12)

All present enzymatic activity of uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12):
3.4.24.65;

The structure of uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12) also contains other interesting chemical elements:

Calcium

(Ca)

60 atoms

The binding sites of Zinc atom in the uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12) (pdb code 2poj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12), PDB code: 2poj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn264 b:52.1 occ:1.00 NE2 A:HIS218 2.2 43.3 1.0 NE2 A:HIS228 2.2 13.5 1.0 NE2 A:HIS222 2.2 35.4 1.0 CE1 A:HIS218 3.0 12.3 1.0 CD2 A:HIS228 3.1 54.3 1.0 HE1 A:HIS218 3.2 1.1 1.0 CD2 A:HIS222 3.2 21.2 1.0 CE1 A:HIS222 3.2 44.4 1.0 CE1 A:HIS228 3.2 63.1 1.0 HD2 A:HIS228 3.3 55.3 1.0 CD2 A:HIS218 3.3 23.4 1.0 HD2 A:HIS222 3.4 71.4 1.0 HE1 A:HIS222 3.4 62.5 1.0 HE1 A:HIS228 3.5 42.5 1.0 HD2 A:HIS218 3.6 1.5 1.0 O A:MET236 3.8 34.1 1.0 HA A:PRO238 3.9 1.2 1.0 ND1 A:HIS218 4.2 73.0 1.0 CG A:HIS228 4.3 5.3 1.0 ND1 A:HIS228 4.3 72.3 1.0 ND1 A:HIS222 4.3 64.2 1.0 CG A:HIS222 4.3 3.2 1.0 CG A:HIS218 4.4 30.4 1.0 HA A:MET236 4.5 3.4 1.0 O A:PHE237 4.5 61.1 1.0 HE3 A:MET236 4.6 70.1 1.0 C A:MET236 4.7 23.6 1.0 CA A:PRO238 4.9 23.4 1.0 C A:PHE237 5.0 54.2 1.0

Zinc binding site 2 out of 2 in the uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structure of the Inhibitor-Free State of Macrophage Metalloelastase (Mmp-12) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn265 b:51.1 occ:1.00 HD1 A:HIS196 1.7 63.2 1.0 OD2 A:ASP170 2.1 5.1 1.0 NE2 A:HIS183 2.1 35.3 1.0 NE2 A:HIS168 2.1 62.3 1.0 ND1 A:HIS196 2.3 11.3 1.0 CE1 A:HIS183 2.9 61.2 1.0 HB2 A:ASP170 2.9 62.1 1.0 CE1 A:HIS168 2.9 23.2 1.0 CG A:ASP170 3.0 2.2 1.0 HE1 A:HIS183 3.0 61.1 1.0 HE1 A:HIS168 3.0 41.1 1.0 HB3 A:ASP170 3.1 24.3 1.0 CG A:HIS196 3.1 25.3 1.0 HB2 A:HIS196 3.1 31.5 1.0 CE1 A:HIS196 3.1 71.2 1.0 CB A:ASP170 3.2 53.2 1.0 CD2 A:HIS183 3.2 5.1 1.0 CD2 A:HIS168 3.3 75.3 1.0 HB3 A:HIS196 3.4 44.2 1.0 CE1 A:HIS172 3.4 51.1 1.0 CB A:HIS196 3.4 2.5 1.0 HE1 A:HIS196 3.4 13.2 1.0 HE1 A:HIS172 3.5 54.2 1.0 HD2 A:HIS183 3.6 13.6 1.0 HD2 A:HIS168 3.6 4.3 1.0 NE2 A:HIS172 3.6 51.2 1.0 ND1 A:HIS172 3.7 73.4 1.0 HD1 A:HIS172 4.0 14.1 1.0 ND1 A:HIS183 4.1 34.2 1.0 CD2 A:HIS172 4.1 43.5 1.0 CD2 A:HIS196 4.1 52.4 1.0 NE2 A:HIS196 4.1 12.3 1.0 CG A:HIS172 4.1 2.1 1.0 OD1 A:ASP170 4.1 75.5 1.0 ND1 A:HIS168 4.1 33.4 1.0 CG A:HIS183 4.3 24.4 1.0 CG A:HIS168 4.3 21.0 1.0 HE2 A:PHE174 4.5 63.4 1.0 CA A:ASP170 4.7 12.2 1.0 HB3 A:HIS172 4.7 11.4 1.0 CE2 A:PHE174 4.7 53.2 1.0 HD2 A:HIS172 4.7 31.0 1.0 HZ A:PHE174 4.7 75.1 1.0 O A:HIS183 4.8 31.3 1.0 CZ A:PHE174 4.8 74.4 1.0 HB3 A:ALA164 4.8 74.3 1.0 HD1 A:HIS183 4.9 12.2 1.0 CA A:HIS196 4.9 23.4 1.0 HD1 A:HIS168 5.0 41.1 1.0

R.Bhaskaran, M.O.Palmier, N.A.Bagegni, X.Liang, S.R.Van Doren. Solution Structure of Inhibitor-Free Human Metalloelastase (Mmp-12) Indicates An Internal Conformational Adjustment. J.Mol.Biol. V. 374 1333 2007.
ISSN: ISSN 0022-2836
PubMed: 17997411
DOI: 10.1016/J.JMB.2007.10.028