Zinc in PDB 2m6n: 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1)

The binding sites of Zinc atom in the 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1) (pdb code 2m6n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1), PDB code: 2m6n:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn101 b:51.2 occ:1.00 HB2 A:ARG19 2.8 21.2 1.0 HB3 A:SER22 3.1 60.2 1.0 HB3 A:CYS17 3.2 11.1 1.0 HG A:CYS35 3.2 20.1 1.0 SG A:CYS35 3.2 73.4 1.0 SG A:CYS17 3.2 12.2 1.0 SG A:CYS20 3.2 71.4 1.0 SG A:CYS40 3.2 3.3 1.0 HB2 A:CYS40 3.3 61.5 1.0 H A:CYS20 3.3 12.3 1.0 HG A:CYS20 3.5 41.1 1.0 CB A:CYS17 3.5 41.2 1.0 HB2 A:CYS17 3.5 25.3 1.0 HD3 A:ARG37 3.6 43.4 1.0 CB A:CYS40 3.8 52.5 1.0 CB A:ARG19 3.8 13.2 1.0 HG3 A:ARG19 3.9 20.4 1.0 HE1 A:PHE42 3.9 61.2 1.0 HD3 A:ARG19 4.0 54.2 1.0 HB3 A:ARG37 4.0 32.1 1.0 CB A:SER22 4.1 40.3 1.0 HB3 A:CYS40 4.1 24.2 1.0 HB2 A:ARG37 4.2 43.3 1.0 HB3 A:ARG19 4.2 4.4 1.0 N A:CYS20 4.2 40.2 1.0 H A:SER22 4.2 3.1 1.0 CG A:ARG19 4.3 53.3 1.0 HB2 A:SER22 4.3 3.3 1.0 H A:ARG19 4.3 70.0 1.0 HG A:CYS40 4.4 13.4 1.0 CD A:ARG37 4.5 15.4 1.0 HG A:CYS17 4.5 23.1 1.0 CB A:ARG37 4.5 54.4 1.0 CD A:ARG19 4.5 14.4 1.0 HD2 A:ARG37 4.6 34.1 1.0 HB2 A:CYS35 4.6 51.2 1.0 CB A:CYS35 4.6 1.3 1.0 OG A:SER22 4.7 55.0 1.0 HG A:SER22 4.7 23.0 1.0 HD2 A:ARG19 4.7 53.4 1.0 CB A:CYS20 4.7 44.3 1.0 HH11 A:ARG37 4.8 2.4 1.0 CA A:ARG19 4.8 51.2 1.0 HG2 A:ARG37 4.9 20.2 1.0 N A:SER22 4.9 72.4 1.0 CG A:ARG37 4.9 3.4 1.0 HB3 A:CYS35 5.0 23.2 1.0 CA A:CYS20 5.0 64.1 1.0 H A:ASN21 5.0 5.0 1.0 CE1 A:PHE42 5.0 70.5 1.0 N A:ARG19 5.0 35.1 1.0

Zinc binding site 2 out of 2 in the 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 3D Solution Structure of EMI1 (Early Mitotic Inhibitor 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn102 b:51.1 occ:1.00 HB2 A:CYS45 2.9 4.4 1.0 NE2 A:HIS53 3.0 3.2 1.0 HG A:CYS45 3.1 54.2 1.0 HD2 A:HIS53 3.2 21.2 1.0 SG A:CYS48 3.2 44.0 1.0 SG A:CYS58 3.2 23.3 1.0 SG A:CYS45 3.2 72.2 1.0 CB A:CYS45 3.4 65.3 1.0 CD2 A:HIS53 3.4 32.4 1.0 HB3 A:CYS45 3.4 22.2 1.0 HG A:CYS48 3.6 24.4 1.0 HG A:CYS58 3.6 35.2 1.0 O A:ASN51 4.1 45.3 1.0 CE1 A:HIS53 4.2 25.1 1.0 HA A:TYR52 4.2 61.0 1.0 H A:HIS53 4.5 34.0 1.0 HB2 A:LYS47 4.6 30.0 1.0 H A:CYS48 4.6 45.5 1.0 HE1 A:HIS53 4.6 34.4 1.0 CG A:HIS53 4.7 51.5 1.0 CB A:CYS48 4.8 21.1 1.0 HB3 A:CYS48 4.8 22.4 1.0 CB A:CYS58 4.8 64.1 1.0 H A:CYS45 4.9 45.2 1.0 CA A:CYS45 4.9 33.2 1.0 HB2 A:CYS58 4.9 3.4 1.0 ND1 A:HIS53 5.0 23.3 1.0

J.J.Frye, N.G.Brown, G.Petzold, E.R.Watson, C.R.Grace, A.Nourse, M.A.Jarvis, R.W.Kriwacki, J.M.Peters, H.Stark, B.A.Schulman. Electron Microscopy Structure of Human Apc/C(CDH1)-EMI1 Reveals Multimodal Mechanism of E3 Ligase Shutdown. Nat.Struct.Mol.Biol. V. 20 827 2013.
ISSN: ISSN 1545-9993
PubMed: 23708605
DOI: 10.1038/NSMB.2593