Zinc in PDB 2m3z: uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry

The binding sites of Zinc atom in the uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry (pdb code 2m3z). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry, PDB code: 2m3z:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn101 b:0.0 occ:1.00 NE2 A:HIS23 2.3 0.0 1.0 SG A:CYS15 2.4 0.0 1.0 SG A:CYS18 2.4 0.0 1.0 SG A:CYS28 2.4 0.0 1.0 H A:CYS18 2.9 0.0 1.0 HB2 A:CYS28 2.9 0.0 1.0 HB3 A:CYS15 3.1 0.0 1.0 CB A:CYS15 3.2 0.0 1.0 HB2 A:CYS15 3.2 0.0 1.0 HB3 A:CYS18 3.2 0.0 1.0 CE1 A:HIS23 3.2 0.0 1.0 CB A:CYS28 3.3 0.0 1.0 CD2 A:HIS23 3.3 0.0 1.0 CB A:CYS18 3.4 0.0 1.0 HE1 A:HIS23 3.4 0.0 1.0 HD2 A:HIS23 3.5 0.0 1.0 HB3 A:ASN17 3.7 0.0 1.0 N A:CYS18 3.7 0.0 1.0 HB3 A:CYS28 4.0 0.0 1.0 HB1 A:ALA30 4.0 0.0 1.0 CA A:CYS18 4.1 0.0 1.0 HA A:ALA25 4.1 0.0 1.0 HA A:CYS28 4.2 0.0 1.0 HB3 A:ALA30 4.2 0.0 1.0 H A:GLY19 4.2 0.0 1.0 HB2 A:CYS18 4.3 0.0 1.0 H A:LYS20 4.3 0.0 1.0 H A:ALA30 4.4 0.0 1.0 CA A:CYS28 4.4 0.0 1.0 ND1 A:HIS23 4.4 0.0 1.0 H A:ASN17 4.4 0.0 1.0 CG A:HIS23 4.5 0.0 1.0 HB3 A:LYS20 4.5 0.0 1.0 CB A:ALA30 4.6 0.0 1.0 CA A:CYS15 4.7 0.0 1.0 H A:ARG29 4.7 0.0 1.0 CB A:ASN17 4.7 0.0 1.0 N A:GLY19 4.8 0.0 1.0 C A:CYS18 4.8 0.0 1.0 HD21 A:ASN17 4.8 0.0 1.0 C A:ASN17 4.8 0.0 1.0

Zinc binding site 2 out of 2 in the uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structure of Hiv-1 Nucleocapsid Protein in Complex with An Inhibitor Displaying A 2 Inhibitors:1 Nc Stoichiometry within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn102 b:0.0 occ:1.00 NE2 A:HIS44 2.3 0.0 1.0 SG A:CYS39 2.4 0.0 1.0 SG A:CYS36 2.4 0.0 1.0 SG A:CYS49 2.4 0.0 1.0 HB2 A:CYS49 2.9 0.0 1.0 H A:CYS39 3.1 0.0 1.0 HB3 A:CYS39 3.1 0.0 1.0 HB2 A:CYS36 3.1 0.0 1.0 CB A:CYS36 3.1 0.0 1.0 HB3 A:CYS36 3.1 0.0 1.0 CB A:CYS49 3.2 0.0 1.0 CE1 A:HIS44 3.2 0.0 1.0 CB A:CYS39 3.3 0.0 1.0 HE1 A:HIS44 3.4 0.0 1.0 CD2 A:HIS44 3.4 0.0 1.0 HD2 A:HIS44 3.6 0.0 1.0 N A:CYS39 3.7 0.0 1.0 HB3 A:CYS49 3.7 0.0 1.0 HB3 A:LYS38 4.0 0.0 1.0 HA A:MET46 4.0 0.0 1.0 CA A:CYS39 4.0 0.0 1.0 HZ3 A:LYS38 4.1 0.0 1.0 HB2 A:CYS39 4.2 0.0 1.0 H A:LYS41 4.2 0.0 1.0 H A:GLY40 4.2 0.0 1.0 HB2 A:LYS41 4.3 0.0 1.0 ND1 A:HIS44 4.4 0.0 1.0 HA A:CYS49 4.4 0.0 1.0 CA A:CYS49 4.5 0.0 1.0 H A:LYS38 4.5 0.0 1.0 CG A:HIS44 4.5 0.0 1.0 CA A:CYS36 4.6 0.0 1.0 C A:LYS38 4.7 0.0 1.0 C A:CYS39 4.8 0.0 1.0 N A:GLY40 4.8 0.0 1.0 HB3 A:MET46 4.9 0.0 1.0 CB A:LYS38 4.9 0.0 1.0 HA A:CYS39 4.9 0.0 1.0 HA A:CYS36 5.0 0.0 1.0 NZ A:LYS38 5.0 0.0 1.0

N.Goudreau, O.Hucke, A.M.Faucher, C.Grand-Maitre, O.Lepage, P.R.Bonneau, S.W.Mason, S.Titolo. Discovery and Structural Characterization of A New Inhibitor Series of Hiv-1 Nucleocapsid Function: uc(Nmr) Solution Structure Determination of A Ternary Complex Involving A 2:1 Inhibitor/Nc Stoichiometry. J.Mol.Biol. V. 425 1982 2013.
ISSN: ISSN 0022-2836
PubMed: 23485336
DOI: 10.1016/J.JMB.2013.02.022