Zinc in PDB 2j1x: Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D

The structure of Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D, PDB code: 2j1x was solved by A.C.Joerger, A.R.Fersht, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.80 / 1.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	64.501, 71.109, 104.897, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 20.6

The binding sites of Zinc atom in the Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D (pdb code 2j1x). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D, PDB code: 2j1x:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn313 b:18.5 occ:1.00 ND1 A:HIS179 2.0 10.1 1.0 SG A:CYS242 2.3 12.7 1.0 SG A:CYS238 2.3 14.7 1.0 SG A:CYS176 2.4 10.3 1.0 CE1 A:HIS179 3.0 12.5 1.0 CG A:HIS179 3.1 12.9 1.0 CB A:CYS242 3.1 12.7 1.0 CB A:CYS238 3.4 15.7 1.0 CB A:CYS176 3.4 10.8 1.0 CB A:HIS179 3.4 11.8 1.0 CA A:CYS238 3.8 10.9 1.0 O A:HOH2110 3.8 27.2 1.0 N A:CYS176 4.0 8.6 1.0 NE2 A:HIS179 4.1 13.5 1.0 CD2 A:HIS179 4.2 12.8 1.0 CA A:CYS176 4.3 9.4 1.0 N A:TYR239 4.3 8.9 1.0 N A:HIS179 4.3 10.3 1.0 CA A:HIS179 4.5 11.3 1.0 CA A:CYS242 4.5 12.3 1.0 C A:CYS238 4.6 10.2 1.0 O A:HOH2095 4.7 14.0 1.0 O A:MET237 4.7 10.4 1.0

Zinc binding site 2 out of 2 in the Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human P53 Core Domain Mutant M133L-V203A-Y220C-N239Y-N268D within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn313 b:18.9 occ:1.00 ND1 B:HIS179 2.1 12.0 1.0 SG B:CYS242 2.3 12.1 1.0 SG B:CYS238 2.3 10.6 1.0 SG B:CYS176 2.4 9.8 1.0 CE1 B:HIS179 3.0 13.5 1.0 CG B:HIS179 3.1 11.8 1.0 CB B:CYS242 3.1 13.1 1.0 CB B:CYS238 3.4 11.9 1.0 CB B:HIS179 3.4 12.6 1.0 CB B:CYS176 3.4 10.4 1.0 O B:HOH2104 3.8 27.4 1.0 CA B:CYS238 3.8 8.5 1.0 N B:CYS176 4.0 8.2 1.0 NE2 B:HIS179 4.1 14.6 1.0 CD2 B:HIS179 4.2 13.3 1.0 CA B:CYS176 4.3 9.7 1.0 N B:HIS179 4.3 10.4 1.0 N B:TYR239 4.4 8.9 1.0 CA B:CYS242 4.5 12.4 1.0 CA B:HIS179 4.5 11.2 1.0 O B:HOH2093 4.6 14.6 1.0 O B:MET237 4.6 10.7 1.0 C B:CYS238 4.7 8.1 1.0

A.C.Joerger, H.C.Ang, A.R.Fersht. Structural Basis For Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.Usa V. 103 15056 2006.
ISSN: ISSN 0027-8424
PubMed: 17015838
DOI: 10.1073/PNAS.0607286103