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Zinc in PDB 1uzf: Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme

Enzymatic activity of Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme

All present enzymatic activity of Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme:
3.4.15.1;

Protein crystallography data

The structure of Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme, PDB code: 1uzf was solved by R.Natesh, S.L.U.Schwager, H.R.Evans, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50 / 2.0
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.650, 84.900, 133.500, 90.00, 90.00, 90.00
R / Rfree (%) 18.4 / 22.7

Other elements in 1uzf:

The structure of Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme (pdb code 1uzf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme, PDB code: 1uzf:

Zinc binding site 1 out of 1 in 1uzf

Go back to Zinc Binding Sites List in 1uzf
Zinc binding site 1 out of 1 in the Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of the Anti-Hypertensive Drug Captopril An the Human Testicular Angiotensin I-Converting Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:17.7
occ:1.00
 OE1 A:GLU411 2.0 11.5 1.0
NE2 A:HIS383 2.1 16.2 1.0
NE2 A:HIS387 2.1 19.8 1.0
S A:MCO702 2.3 24.8 1.0
CD A:GLU411 2.9 11.2 1.0
C1 A:MCO702 3.0 21.4 1.0
CD2 A:HIS383 3.0 14.4 1.0
CD2 A:HIS387 3.1 17.9 1.0
CE1 A:HIS387 3.1 18.9 1.0
CE1 A:HIS383 3.1 16.5 1.0
OE2 A:GLU411 3.2 10.6 1.0
C2 A:MCO702 3.6 20.7 1.0
OE2 A:GLU384 4.1 16.4 1.0
CG A:HIS383 4.1 16.4 1.0
ND1 A:HIS383 4.2 14.1 1.0
ND1 A:HIS387 4.2 19.2 1.0
C3 A:MCO702 4.2 20.0 1.0
CG A:HIS387 4.2 17.5 1.0
CG A:GLU411 4.3 13.7 1.0
O A:HOH2356 4.4 15.8 1.0
CE2 A:TYR523 4.5 12.1 1.0
CA A:GLU411 4.6 14.3 1.0
CB A:GLU411 4.7 13.6 1.0
CD A:GLU384 4.7 18.4 1.0
OE1 A:GLU384 4.7 19.2 1.0
C5 A:MCO702 4.8 20.1 1.0
C4 A:MCO702 4.9 20.1 1.0

Reference:

R.Natesh, S.L.U.Schwager, H.R.Evans, E.D.Sturrock, K.R.Acharya. Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme Biochemistry V. 43 8718 2004.
ISSN: ISSN 0006-2960
PubMed: 15236580
DOI: 10.1021/BI049480N
Page generated: Wed Oct 16 19:40:44 2024

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