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Zinc in PDB 1tqt: Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol

Enzymatic activity of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol

All present enzymatic activity of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol, PDB code: 1tqt was solved by D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.17 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.887, 109.740, 138.656, 90.00, 90.00, 90.00
R / Rfree (%) 14.6 / 18.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol (pdb code 1tqt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol, PDB code: 1tqt:

Zinc binding site 1 out of 1 in 1tqt

Go back to Zinc Binding Sites List in 1tqt
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II in Complex with A Diastereomer of Salacinol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1301

b:12.6
occ:1.00
OD1 A:ASP92 2.1 11.5 1.0
NE2 A:HIS90 2.1 4.2 1.0
NE2 A:HIS471 2.2 9.7 1.0
OD1 A:ASP204 2.2 7.3 1.0
O2 A:SSD1201 2.3 17.1 1.0
CG A:ASP92 2.9 9.9 1.0
OD2 A:ASP92 3.0 10.3 1.0
CD2 A:HIS90 3.0 4.9 1.0
CD2 A:HIS471 3.1 8.3 1.0
CE1 A:HIS90 3.1 6.4 1.0
CG A:ASP204 3.1 10.7 1.0
CE1 A:HIS471 3.2 8.3 1.0
C2 A:SSD1201 3.2 15.8 1.0
C3 A:SSD1201 3.3 18.4 1.0
CB A:ASP204 3.4 7.9 1.0
C1 A:SSD1201 4.0 16.5 1.0
OD2 A:ASP472 4.0 10.0 1.0
CG A:HIS90 4.2 4.6 1.0
ND1 A:HIS90 4.2 6.6 1.0
CG A:HIS471 4.2 8.2 1.0
OD2 A:ASP204 4.3 9.7 1.0
ND1 A:HIS471 4.3 8.7 1.0
CB A:ASP92 4.3 8.3 1.0
CE1 A:HIS470 4.3 10.6 1.0
O A:HOH1448 4.4 9.1 1.0
S4 A:SSD1201 4.4 17.6 1.0
OH A:TYR269 4.9 9.3 1.0
O1 A:SSD1201 4.9 14.0 1.0
CA A:ASP204 4.9 9.1 1.0
CA A:ASP92 4.9 9.1 1.0
NE2 A:HIS470 4.9 9.9 1.0
CG A:ASP472 4.9 7.8 1.0

Reference:

D.A.Kuntz, A.Ghavami, B.D.Johnston, B.M.Pinto, D.R.Rose. Crystallographic Analysis of the Interactions of Drosophila Melanogaster Golgi Alpha-Mannosidase II with the Naturally Occurring Glycomimetic Salacinol and Its Analogues Tetrahedron Asymmetry V. 16 25 2005.
ISSN: ISSN 0957-4166
Page generated: Wed Dec 16 03:05:16 2020

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