Atomistry » Zinc » PDB 1my0-1ndv » 1n9a
Atomistry »
  Zinc »
    PDB 1my0-1ndv »
      1n9a »

Zinc in PDB 1n9a: Farnesyltransferase Complex with Tetrahydropyridine Inhibitors

Protein crystallography data

The structure of Farnesyltransferase Complex with Tetrahydropyridine Inhibitors, PDB code: 1n9a was solved by S.L.Gwaltney Ii, S.J.O'conner, L.T.Nelson, G.M.Sullivan, H.Imade, W.Wang, L.Hasvold, Q.Li, J.Cohen, W.Z.Gu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.12 / 3.20
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 170.503, 170.503, 69.272, 90.00, 90.00, 120.00
R / Rfree (%) 32.9 / 37.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Farnesyltransferase Complex with Tetrahydropyridine Inhibitors (pdb code 1n9a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Farnesyltransferase Complex with Tetrahydropyridine Inhibitors, PDB code: 1n9a:

Zinc binding site 1 out of 1 in 1n9a

Go back to Zinc Binding Sites List in 1n9a
Zinc binding site 1 out of 1 in the Farnesyltransferase Complex with Tetrahydropyridine Inhibitors


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Farnesyltransferase Complex with Tetrahydropyridine Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn500

b:30.0
occ:1.00
OD2 B:ASP297 1.8 55.7 1.0
SG B:CYS299 2.2 36.3 1.0
NE2 B:HIS362 2.3 32.3 1.0
CG B:ASP297 2.4 55.7 1.0
OD1 B:ASP297 2.4 55.7 1.0
CD2 B:HIS362 3.2 32.3 1.0
CB B:CYS299 3.3 36.3 1.0
CE1 B:HIS362 3.4 32.3 1.0
N2 B:FTI1 3.5 30.0 1.0
CB B:ASP297 3.8 55.7 1.0
CE2 B:TYR361 3.9 15.1 1.0
N B:CYS299 3.9 53.5 1.0
CA B:CYS299 4.3 53.5 1.0
CG B:HIS362 4.3 32.3 1.0
OD2 B:ASP352 4.4 33.3 1.0
ND1 B:HIS362 4.4 32.3 1.0
C19 B:FTI1 4.4 30.0 1.0
C17 B:FTI1 4.5 30.0 1.0
CG B:ASP352 4.5 33.3 1.0
OH B:TYR361 4.5 15.1 1.0
CB B:ASP352 4.7 33.3 1.0
CE1 B:TYR300 4.7 69.0 1.0
CZ B:TYR361 4.7 15.1 1.0
C B:ASP297 4.8 70.0 1.0
CD2 B:TYR361 4.8 15.1 1.0
CA B:ASP297 4.8 70.0 1.0
CD1 B:TYR300 4.9 69.0 1.0
CA B:ASP352 4.9 88.2 1.0
N B:GLY298 5.0 55.1 1.0

Reference:

S.L.Gwaltney Ii, S.J.O'connor, L.T.Nelson, G.M.Sullivan, H.Imade, W.Wang, L.Hasvold, Q.Li, J.Cohen, W.Z.Gu, S.K.Tahir, J.Bauch, K.Marsh, S.C.Ng, D.J.Frost, H.Zhang, S.Muchmore, C.G.Jakob, V.Stoll, C.Hutchins, S.H.Rosenberg, H.L.Sham. Aryl Tetrahydropyridine Inhibitors of Farnesyltransferase: Bioavailable Analogues with Improved Cellular Potency. Bioorg.Med.Chem.Lett. V. 13 1363 2003.
ISSN: ISSN 0960-894X
PubMed: 12657283
DOI: 10.1016/S0960-894X(03)00094-5
Page generated: Wed Oct 16 17:13:52 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy