Zinc in PDB 1mzc: Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A

The structure of Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A, PDB code: 1mzc was solved by S.J.Desolms, T.M.Ciccarone, S.C.Mactough, A.W.Shaw, C.A.Buser, M.Ellis-Hutchings, C.Fernandes, K.A.Hamilton, H.E.Huber, N.E.Kohl, R.B.Lobell, R.G.Robinson, N.N.Tsou, E.S.Walsh, S.L.Graham, L.S.Beese, J.S.Taylor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.70 / 2.00
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	178.385, 178.385, 64.579, 90.00, 90.00, 120.00
R / Rfree (%)	17.7 / 20.5

The binding sites of Zinc atom in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A (pdb code 1mzc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A, PDB code: 1mzc:

Zinc binding site 1 out of 1 in the Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Co-Crystal Structure of Human Farnesyltransferase with Farnesyldiphosphate and Inhibitor Compound 33A within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:16.3 occ:1.00 NZ B:BNE1003 1.9 15.6 1.0 OD2 B:ASP797 2.1 14.1 1.0 NE2 B:HIS862 2.1 12.9 1.0 SG B:CYS799 2.4 12.2 1.0 OD1 B:ASP797 2.6 13.3 1.0 CG B:ASP797 2.6 14.4 1.0 C33 B:BNE1003 2.8 15.1 1.0 CD2 B:HIS862 3.0 13.1 1.0 C32 B:BNE1003 3.1 14.4 1.0 CE1 B:HIS862 3.1 12.7 1.0 CB B:CYS799 3.3 11.7 1.0 CE2 B:TYR861 3.8 11.3 1.0 N31 B:BNE1003 4.0 15.3 1.0 CB B:ASP797 4.0 14.0 1.0 N B:CYS799 4.1 12.4 1.0 CG B:HIS862 4.1 13.3 1.0 ND1 B:HIS862 4.2 13.2 1.0 C28 B:BNE1003 4.2 15.8 1.0 CA B:CYS799 4.3 12.4 1.0 CB B:ASP852 4.4 15.2 1.0 OH B:TYR861 4.4 12.4 1.0 O B:HOH1079 4.5 11.9 1.0 CG B:ASP852 4.5 15.6 1.0 CZ B:TYR861 4.6 12.5 1.0 CD2 B:TYR861 4.6 12.7 1.0 OD2 B:ASP852 4.7 16.6 1.0 CA B:ASP852 4.8 15.5 1.0

S.J.Desolms, T.M.Ciccarone, S.C.Mactough, A.W.Shaw, C.A.Buser, M.Ellis-Hutchings, C.Fernandes, K.A.Hamilton, H.E.Huber, N.E.Kohl, R.B.Lobell, R.G.Robinson, N.N.Tsou, E.S.Walsh, S.L.Graham, L.S.Beese, J.S.Taylor. Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors As Potential Cancer Chemotherapeutic Agents. J.Med.Chem. V. 46 2973 2003.
ISSN: ISSN 0022-2623
PubMed: 12825937
DOI: 10.1021/JM020587N