Atomistry » Zinc » PDB 1jpu-1k51 » 1k4g
Atomistry »
  Zinc »
    PDB 1jpu-1k51 »
      1k4g »

Zinc in PDB 1k4g: Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One

Enzymatic activity of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One

All present enzymatic activity of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One:
2.4.2.29;

Protein crystallography data

The structure of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One, PDB code: 1k4g was solved by R.Brenk, E.A.Meyer, R.K.Castellano, M.Furler, M.T.Stubbs, G.Klebe, F.Diederich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.80 / 1.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 89.767, 64.749, 71.130, 90.00, 95.92, 90.00
R / Rfree (%) 19.9 / 24.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One (pdb code 1k4g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One, PDB code: 1k4g:

Zinc binding site 1 out of 1 in 1k4g

Go back to Zinc Binding Sites List in 1k4g
Zinc binding site 1 out of 1 in the Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Trna-Guanine Transglycosylase (Tgt) Complexed with 2,6-Diamino-8-(1H-Imidazol-2-Ylsulfanylmethyl)-3H-Quinazoline-4- One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn400

b:11.9
occ:1.00
 ND1 A:HIS349 2.2 12.5 1.0
SG A:CYS323 2.3 12.9 1.0
SG A:CYS320 2.3 13.1 1.0
SG A:CYS318 2.4 13.8 1.0
CE1 A:HIS349 3.1 11.4 1.0
CB A:CYS323 3.3 12.8 1.0
CB A:CYS318 3.3 13.9 1.0
CG A:HIS349 3.3 10.3 1.0
CB A:CYS320 3.4 10.5 1.0
CB A:HIS349 3.7 9.7 1.0
N A:CYS323 3.9 12.5 1.0
CA A:HIS349 4.1 9.3 1.0
CA A:CYS323 4.2 12.0 1.0
N A:CYS320 4.2 12.4 1.0
NE2 A:HIS349 4.2 11.6 1.0
CA A:CYS320 4.2 11.7 1.0
CD2 A:HIS349 4.4 11.3 1.0
O A:HIS349 4.6 8.7 1.0
CA A:CYS318 4.6 14.8 1.0
O A:CYS320 4.6 11.6 1.0
C A:CYS320 4.7 11.0 1.0
C A:CYS318 4.7 14.4 1.0
CB A:VAL322 4.7 10.5 1.0
C A:HIS349 4.8 9.6 1.0
O A:CYS318 4.8 15.7 1.0
C A:VAL322 4.9 12.7 1.0

Reference:

E.A.Meyer, R.Brenk, R.K.Castellano, M.Furler, G.Klebe, F.Diederich. De Novo Design, Synthesis, and in Vitro Evaluation of Inhibitors For Prokaryotic Trna-Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity. Chembiochem V. 3 250 2002.
ISSN: ISSN 1439-4227
PubMed: 11921407
DOI: 10.1002/1439-7633(20020301)3:2/3<250::AID-CBIC250>3.0.CO;2-J
Page generated: Sun Oct 13 04:02:03 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy