Zinc in PDB 1jzq: Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue

All present enzymatic activity of Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue:
6.1.1.5;

The structure of Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue, PDB code: 1jzq was solved by T.Nakama, O.Nureki, S.Yokoyama, Riken Structuralgenomics/Proteomics Initiative (Rsgi), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 3.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	160.470, 95.190, 126.210, 90.00, 126.22, 90.00
R / Rfree (%)	22 / 27.2

The binding sites of Zinc atom in the Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue (pdb code 1jzq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue, PDB code: 1jzq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:42.2 occ:1.00 SG A:CYS184 2.4 33.7 1.0 SG A:CYS392 2.5 37.6 1.0 SG A:CYS181 2.5 45.9 1.0 SG A:CYS389 2.5 43.2 1.0 CB A:CYS389 3.0 40.5 1.0 CB A:CYS181 3.5 38.4 1.0 CB A:CYS184 3.7 29.9 1.0 O A:CYS392 3.9 46.5 1.0 CB A:CYS392 4.0 37.9 1.0 CG A:ARG183 4.2 34.3 1.0 N A:CYS392 4.2 37.4 1.0 N A:CYS184 4.4 35.4 1.0 CA A:CYS389 4.5 41.5 1.0 CA A:CYS392 4.6 39.4 1.0 CA A:CYS184 4.6 32.2 1.0 C A:CYS392 4.7 42.4 1.0 CB A:THR394 4.7 38.4 1.0 OG1 A:THR394 4.8 45.9 1.0 CA A:CYS181 4.9 38.2 1.0 CB A:ARG391 4.9 43.3 1.0

Zinc binding site 2 out of 2 in the Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Isoleucyl-Trna Synthetase Complexed with Isoleucyl- Adenylate Analogue within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1102 b:93.7 occ:1.00 SG A:CYS502 2.4 86.6 1.0 SG A:CYS461 2.5 69.5 1.0 CB A:CYS464 2.6 93.5 1.0 SG A:CYS504 2.7 82.9 1.0 CA A:CYS464 3.3 89.3 1.0 CB A:CYS461 3.4 69.9 1.0 N A:GLY465 3.4 87.5 1.0 N A:CYS464 3.4 88.2 1.0 C A:CYS464 3.5 87.8 1.0 CB A:CYS502 3.5 83.3 1.0 SG A:CYS464 3.6 0.9 1.0 CB A:CYS504 3.7 84.1 1.0 O A:GLY465 4.0 83.9 1.0 O A:CYS464 4.2 86.7 1.0 CA A:GLY465 4.3 86.1 1.0 C A:GLY465 4.4 83.1 1.0 N A:CYS504 4.4 85.8 1.0 C A:ALA463 4.6 86.5 1.0 CA A:CYS504 4.6 86.1 1.0 CA A:CYS461 4.8 71.1 1.0 CA A:CYS502 4.8 82.1 1.0 N A:GLY506 4.9 86.0 1.0

T.Nakama, O.Nureki, S.Yokoyama. Structural Basis For the Recognition of Isoleucyl-Adenylate and An Antibiotic, Mupirocin, By Isoleucyl-Trna Synthetase. J.Biol.Chem. V. 276 47387 2001.
ISSN: ISSN 0021-9258
PubMed: 11584022
DOI: 10.1074/JBC.M109089200