Zinc in PDB 1c3s: Crystal Structure of An Hdac Homolog Complexed with Saha

The structure of Crystal Structure of An Hdac Homolog Complexed with Saha, PDB code: 1c3s was solved by M.S.Finnin, J.R.Donigian, N.P.Pavletich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	51.495, 94.155, 78.977, 90.00, 97.02, 90.00
R / Rfree (%)	20 / 27.7

The binding sites of Zinc atom in the Crystal Structure of An Hdac Homolog Complexed with Saha (pdb code 1c3s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of An Hdac Homolog Complexed with Saha, PDB code: 1c3s:

Zinc binding site 1 out of 1 in the Crystal Structure of An Hdac Homolog Complexed with Saha


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Hdac Homolog Complexed with Saha within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn951 b:27.4 occ:1.00 O1 A:SHH952 1.8 31.9 1.0 OD2 A:ASP258 1.9 24.1 1.0 OD2 A:ASP168 1.9 21.8 1.0 ND1 A:HIS170 2.2 18.1 1.0 O2 A:SHH952 2.7 33.5 1.0 N1 A:SHH952 2.8 34.0 1.0 CE1 A:HIS170 2.8 18.9 1.0 CG A:ASP168 2.9 21.4 1.0 C1 A:SHH952 2.9 34.2 1.0 CG A:ASP258 3.0 26.3 1.0 CG A:HIS170 3.2 17.6 1.0 OD1 A:ASP168 3.3 22.4 1.0 OD1 A:ASP258 3.5 26.9 1.0 N A:HIS170 3.8 18.7 1.0 CB A:HIS170 3.8 18.8 1.0 NE2 A:HIS170 3.9 19.7 1.0 C2 A:SHH952 4.0 36.9 1.0 CD2 A:HIS170 4.1 18.8 1.0 CA A:GLY295 4.1 22.8 1.0 N A:ALA169 4.2 18.0 1.0 CB A:ASP258 4.2 25.5 1.0 CB A:ASP168 4.3 20.4 1.0 CA A:HIS170 4.4 18.4 1.0 OH A:TYR297 4.5 21.4 1.0 C A:ALA169 4.5 18.6 1.0 N A:GLY295 4.6 24.1 1.0 CB A:ALA169 4.6 17.0 1.0 CA A:ALA169 4.6 17.4 1.0 CE1 A:TYR297 4.7 21.6 1.0 C A:ASP168 4.8 18.4 1.0 NE2 A:HIS131 4.8 17.4 1.0 C A:GLY295 4.9 23.1 1.0 CA A:ASP168 4.9 17.8 1.0

M.S.Finnin, J.R.Donigian, A.Cohen, V.M.Richon, R.A.Rifkind, P.A.Marks, R.Breslow, N.P.Pavletich. Structures of A Histone Deacetylase Homologue Bound to the Tsa and Saha Inhibitors. Nature V. 401 188 1999.
ISSN: ISSN 0028-0836
PubMed: 10490031
DOI: 10.1038/43710