Zinc »
PDB 7ftq-7gqt »
7fud »
Zinc in PDB 7fud: Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One
Enzymatic activity of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One
All present enzymatic activity of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One:
2.7.7.86;
2.7.7.86;
Protein crystallography data
The structure of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One, PDB code: 7fud
was solved by
L.Leibrock,
J.Benz,
K.Groebke-Zbinden,
M.G.Rudolph,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 53.47 / 2.03 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 218.34, 45.44, 88.96, 90, 113.74, 90 |
| R / Rfree (%) | 19.4 / 24.9 |
Other elements in 7fud:
The structure of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One
(pdb code 7fud). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One, PDB code: 7fud:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One, PDB code: 7fud:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 7fud
Go back to
Zinc Binding Sites List in 7fud
Zinc binding site 1 out
of 2 in the Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One within 5.0Å range:
|
Zinc binding site 2 out of 2 in 7fud
Go back to
Zinc Binding Sites List in 7fud
Zinc binding site 2 out
of 2 in the Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Human Cyclic Gmp-Amp Synthase in Complex with 5- Benzyl-2-[[2-Chloro-5-(1-Methylpyrazol-3-Yl)Phenyl]Methylamino]-4H- [1,2,4]Triazolo[1,5-A]Pyrimidin-7-One within 5.0Å range:
|
Reference:
K.Groebke-Zbinden,
A.Vandemeulebroucke,
M.Hilbert,
M.G.Rudolph.
Crystal Structure of A Human Cyclic Gmp-Amp Synthase Complex To Be Published.
Page generated: Tue Oct 29 20:41:08 2024
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
