Zinc in PDB 7f9d: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f9d was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.13 / 2.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.49, 106.13, 145.55, 90, 90, 90
R / Rfree (%)	18.7 / 26.3

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 also contains other interesting chemical elements:

Chlorine	(Cl)	6 atoms
Fluorine	(F)	2 atoms
Calcium	(Ca)	4 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 (pdb code 7f9d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f9d:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:46.9 occ:1.00 SG A:CYS1453 2.2 44.5 1.0 SG A:CYS1497 2.2 50.9 1.0 SG A:CYS1448 2.3 47.7 1.0 SG A:CYS1495 2.5 52.9 1.0 CB A:CYS1497 3.0 47.1 1.0 CB A:CYS1448 3.0 47.3 1.0 CB A:CYS1453 3.3 42.7 1.0 CB A:CYS1495 3.4 48.3 1.0 N A:CYS1448 3.8 53.3 1.0 CA A:CYS1448 4.1 50.8 1.0 N A:CYS1497 4.1 51.8 1.0 CA A:CYS1497 4.1 46.6 1.0 OD1 A:ASN1500 4.4 46.8 1.0 CD1 A:PHE1447 4.4 32.9 1.0 CE1 A:PHE1447 4.4 39.4 1.0 CA A:CYS1453 4.7 46.3 1.0 CB A:ASN1500 4.8 45.2 1.0 CA A:CYS1495 4.9 44.4 1.0 C A:CYS1448 4.9 46.9 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1603 b:58.8 occ:0.65 SG B:CYS1448 2.2 85.5 1.0 SG B:CYS1497 2.3 75.8 1.0 SG B:CYS1495 2.4 72.6 1.0 SG B:CYS1453 2.4 78.3 1.0 CB B:CYS1448 2.9 76.4 1.0 CB B:CYS1453 3.2 71.1 1.0 CB B:CYS1497 3.4 67.7 1.0 CB B:CYS1495 3.4 72.3 1.0 N B:CYS1448 3.8 76.8 1.0 CA B:CYS1448 4.0 75.5 1.0 CE1 B:PHE1447 4.1 57.8 1.0 N B:CYS1497 4.2 80.0 1.0 CD1 B:PHE1447 4.2 51.9 1.0 CA B:CYS1497 4.4 80.0 1.0 CA B:CYS1453 4.7 69.2 1.0 CA B:CYS1495 4.8 67.1 1.0 C B:CYS1448 4.9 74.1 1.0 N B:VAL1496 4.9 70.9 1.0 C B:PHE1447 5.0 74.3 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.