Zinc in PDB 6fp6: Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation

All present enzymatic activity of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation:
1.15.1.1;

The structure of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation, PDB code: 6fp6 was solved by F.A.Sala, G.S.A.Wright, S.V.Antonyuk, R.C.Garratt, S.S.Hasnain, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.01 / 3.00
Space group	P 32
Cell size a, b, c (Å), α, β, γ (°)	181.054, 181.054, 141.102, 90.00, 90.00, 120.00
R / Rfree (%)	18.9 / 23

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 24;

Binding sites:

The binding sites of Zinc atom in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation (pdb code 6fp6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 24 binding sites of Zinc where determined in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation, PDB code: 6fp6:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:55.1 occ:1.00 OD1 A:ASP83 1.9 54.9 1.0 ND1 A:HIS71 2.4 64.8 1.0 ND1 A:HIS80 2.5 59.4 1.0 ND1 A:HIS63 2.5 57.3 1.0 CG A:ASP83 2.7 55.2 1.0 CE1 A:HIS71 2.9 64.2 1.0 OD2 A:ASP83 2.9 56.2 1.0 CG A:HIS71 3.1 65.2 1.0 CG A:HIS80 3.3 59.4 1.0 CG A:HIS63 3.3 57.0 1.0 CE1 A:HIS80 3.4 60.5 1.0 CB A:HIS63 3.4 57.3 1.0 CB A:HIS80 3.5 58.4 1.0 CE1 A:HIS63 3.5 57.2 1.0 NE2 A:HIS71 3.7 64.3 1.0 O A:LYS136 3.8 68.1 1.0 CB A:HIS71 3.8 65.9 1.0 CD2 A:HIS71 3.8 65.1 1.0 CA A:HIS71 4.1 65.9 1.0 CB A:ASP83 4.2 54.7 1.0 CD2 A:HIS80 4.3 60.6 1.0 NE2 A:HIS80 4.4 61.2 1.0 CD2 A:HIS63 4.5 56.9 1.0 NE2 A:HIS63 4.6 57.0 1.0 CA A:ASP83 4.7 53.8 1.0 CA A:HIS80 4.7 58.5 1.0 N A:HIS80 4.8 59.3 1.0 C A:LYS136 4.8 68.9 1.0 N A:ASP83 4.9 53.8 1.0 CA A:HIS63 5.0 57.2 1.0

Zinc binding site 2 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn400 b:49.9 occ:1.00 OD1 B:ASP167 1.9 55.6 1.0 ND1 B:HIS155 2.3 56.9 1.0 ND1 B:HIS164 2.4 56.0 1.0 ND1 B:HIS147 2.5 53.1 1.0 CG B:ASP167 2.7 56.1 1.0 OD2 B:ASP167 2.8 56.5 1.0 CE1 B:HIS155 3.0 56.9 1.0 CG B:HIS164 3.1 56.5 1.0 CG B:HIS147 3.2 52.6 1.0 CG B:HIS155 3.3 57.5 1.0 CE1 B:HIS164 3.3 56.3 1.0 CB B:HIS164 3.4 56.6 1.0 CE1 B:HIS147 3.4 53.4 1.0 CB B:HIS147 3.5 52.4 1.0 CB B:HIS155 3.8 57.4 1.0 NE2 B:HIS155 4.1 57.7 1.0 CB B:ASP167 4.1 56.4 1.0 O B:ILE217 4.2 52.9 1.0 CA B:HIS155 4.2 57.5 1.0 CD2 B:HIS164 4.2 57.0 1.0 CD2 B:HIS155 4.2 58.1 1.0 NE2 B:HIS164 4.3 56.9 1.0 CD2 B:HIS147 4.3 52.6 1.0 NE2 B:HIS147 4.3 53.2 1.0 CD2 B:HIS130 4.6 54.5 1.0 CA B:HIS164 4.6 57.5 1.0 N B:HIS164 4.7 58.5 1.0 CA B:ASP167 4.7 55.8 1.0 N B:ASP167 4.8 55.5 1.0 N B:GLY156 4.8 58.4 1.0

Zinc binding site 3 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:67.6 occ:1.00 OD1 C:ASP83 1.9 73.2 1.0 ND1 C:HIS63 2.5 69.9 1.0 ND1 C:HIS71 2.6 80.5 1.0 ND1 C:HIS80 2.6 75.1 1.0 CG C:ASP83 2.7 73.3 1.0 OD2 C:ASP83 2.8 74.1 1.0 CE1 C:HIS71 3.0 80.1 1.0 CG C:HIS71 3.3 80.6 1.0 CG C:HIS63 3.3 69.3 1.0 CG C:HIS80 3.4 75.0 1.0 CB C:HIS63 3.5 68.9 1.0 CE1 C:HIS63 3.5 70.3 1.0 CE1 C:HIS80 3.5 76.1 1.0 CB C:HIS80 3.6 74.3 1.0 O C:LYS136 3.6 85.1 1.0 NE2 C:HIS71 3.8 80.4 1.0 CB C:HIS71 3.9 81.0 1.0 CD2 C:HIS71 4.0 80.8 1.0 CB C:ASP83 4.1 72.7 1.0 CA C:HIS71 4.2 80.4 1.0 CD2 C:HIS63 4.5 69.4 1.0 CD2 C:HIS80 4.5 75.7 1.0 NE2 C:HIS63 4.5 70.1 1.0 NE2 C:HIS80 4.5 76.5 1.0 CA C:ASP83 4.6 71.5 1.0 N C:HIS80 4.7 76.0 1.0 CA C:HIS80 4.7 74.6 1.0 N C:ASP83 4.7 70.8 1.0 CD2 C:HIS46 4.8 73.6 1.0 C C:LYS136 4.8 86.2 1.0 N C:GLY72 5.0 80.0 1.0 CA C:HIS63 5.0 68.3 1.0

Zinc binding site 4 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn400 b:48.4 occ:1.00 OD1 D:ASP167 2.0 51.4 1.0 ND1 D:HIS155 2.2 51.1 1.0 ND1 D:HIS147 2.4 52.2 1.0 ND1 D:HIS164 2.4 50.9 1.0 CE1 D:HIS155 2.8 51.1 1.0 CG D:ASP167 2.8 51.5 1.0 OD2 D:ASP167 3.0 51.7 1.0 CG D:HIS147 3.1 51.9 1.0 CE1 D:HIS147 3.2 52.3 1.0 CE1 D:HIS164 3.2 51.1 1.0 CG D:HIS155 3.4 51.4 1.0 CG D:HIS164 3.4 51.0 1.0 CB D:HIS147 3.5 51.8 1.0 CB D:HIS164 3.8 50.9 1.0 NE2 D:HIS155 4.0 51.5 1.0 CB D:HIS155 4.0 51.5 1.0 NE2 D:HIS147 4.1 52.3 1.0 CD2 D:HIS147 4.1 52.0 1.0 O D:ILE217 4.1 52.4 1.0 CB D:ASP167 4.2 51.6 1.0 NE2 D:HIS164 4.3 51.3 1.0 CD2 D:HIS155 4.3 51.7 1.0 CA D:HIS155 4.4 51.5 1.0 CD2 D:HIS164 4.4 51.2 1.0 CD2 D:HIS130 4.5 52.5 1.0 CA D:ASP167 4.7 51.4 1.0 N D:ASP167 4.9 51.2 1.0 O D:THR218 4.9 52.5 1.0 N D:GLY156 5.0 51.8 1.0 NE2 D:HIS130 5.0 52.8 1.0 CA D:HIS164 5.0 51.0 1.0

Zinc binding site 5 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn201 b:56.9 occ:1.00 OD1 E:ASP83 1.8 54.0 1.0 ND1 E:HIS80 2.3 58.3 1.0 ND1 E:HIS63 2.5 57.9 1.0 ND1 E:HIS71 2.5 62.2 1.0 CG E:ASP83 2.7 54.2 1.0 OD2 E:ASP83 2.8 54.8 1.0 CE1 E:HIS71 3.0 61.5 1.0 CE1 E:HIS80 3.1 59.2 1.0 CG E:HIS63 3.3 57.7 1.0 CG E:HIS80 3.3 58.5 1.0 CG E:HIS71 3.3 62.5 1.0 CB E:HIS63 3.4 57.8 1.0 CE1 E:HIS63 3.4 57.8 1.0 CB E:HIS80 3.7 58.0 1.0 O E:LYS136 3.7 63.8 1.0 NE2 E:HIS71 3.8 61.7 1.0 CB E:HIS71 3.9 63.3 1.0 CD2 E:HIS71 4.0 62.3 1.0 CB E:ASP83 4.1 54.0 1.0 CA E:HIS71 4.1 63.3 1.0 NE2 E:HIS80 4.2 60.0 1.0 CD2 E:HIS80 4.3 59.5 1.0 CD2 E:HIS63 4.4 57.6 1.0 NE2 E:HIS63 4.4 57.6 1.0 CA E:ASP83 4.6 53.3 1.0 N E:HIS80 4.7 59.1 1.0 N E:ASP83 4.8 53.4 1.0 CA E:HIS80 4.8 58.3 1.0 C E:LYS136 4.8 64.7 1.0 N E:GLY72 4.9 62.5 1.0 CA E:HIS63 5.0 57.9 1.0

Zinc binding site 6 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn400 b:53.2 occ:1.00 OD1 F:ASP167 2.0 56.6 1.0 ND1 F:HIS155 2.4 57.7 1.0 ND1 F:HIS147 2.4 52.8 1.0 ND1 F:HIS164 2.4 57.2 1.0 CG F:ASP167 2.7 57.1 1.0 OD2 F:ASP167 2.8 57.5 1.0 CE1 F:HIS155 3.1 57.8 1.0 CG F:HIS147 3.1 52.4 1.0 CG F:HIS164 3.2 57.4 1.0 CE1 F:HIS147 3.2 53.0 1.0 CE1 F:HIS164 3.3 57.5 1.0 CG F:HIS155 3.4 58.2 1.0 CB F:HIS147 3.4 52.3 1.0 CB F:HIS164 3.5 57.5 1.0 CB F:HIS155 3.8 58.4 1.0 O F:ILE217 4.0 57.2 1.0 CD2 F:HIS147 4.1 52.4 1.0 CA F:HIS155 4.2 58.4 1.0 NE2 F:HIS147 4.2 52.8 1.0 CB F:ASP167 4.2 57.3 1.0 NE2 F:HIS155 4.2 58.2 1.0 CD2 F:HIS164 4.2 57.8 1.0 NE2 F:HIS164 4.3 58.0 1.0 CD2 F:HIS155 4.4 58.6 1.0 CD2 F:HIS130 4.7 56.2 1.0 CA F:HIS164 4.7 58.3 1.0 CA F:ASP167 4.8 56.9 1.0 N F:HIS164 4.8 59.1 1.0 N F:GLY156 4.9 59.5 1.0 CA F:HIS147 4.9 52.1 1.0 N F:ASP167 5.0 56.6 1.0

Zinc binding site 7 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn201 b:48.1 occ:1.00 OD1 G:ASP83 1.9 51.9 1.0 ND1 G:HIS71 2.4 57.4 1.0 ND1 G:HIS80 2.4 54.8 1.0 ND1 G:HIS63 2.5 53.5 1.0 CG G:ASP83 2.7 52.1 1.0 OD2 G:ASP83 2.8 52.5 1.0 CE1 G:HIS71 2.9 56.9 1.0 CG G:HIS71 3.2 57.7 1.0 CG G:HIS80 3.3 54.9 1.0 CE1 G:HIS80 3.3 55.4 1.0 CG G:HIS63 3.3 53.6 1.0 CB G:HIS63 3.4 53.8 1.0 CE1 G:HIS63 3.5 53.5 1.0 CB G:HIS80 3.6 54.5 1.0 CB G:HIS71 3.8 58.4 1.0 O G:LYS136 3.8 58.6 1.0 NE2 G:HIS71 3.9 57.0 1.0 CD2 G:HIS71 4.1 57.5 1.0 CA G:HIS71 4.1 58.6 1.0 CB G:ASP83 4.1 52.0 1.0 NE2 G:HIS80 4.3 55.9 1.0 CD2 G:HIS80 4.3 55.6 1.0 CD2 G:HIS63 4.5 53.5 1.0 NE2 G:HIS63 4.5 53.5 1.0 N G:HIS80 4.6 55.4 1.0 CA G:ASP83 4.7 51.6 1.0 CA G:HIS80 4.7 54.8 1.0 N G:ASP83 4.7 51.7 1.0 C G:LYS136 4.9 59.1 1.0 N G:GLY72 4.9 58.0 1.0 CA G:HIS63 5.0 53.9 1.0

Zinc binding site 8 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn400 b:48.4 occ:1.00 OD1 H:ASP167 1.9 55.6 1.0 ND1 H:HIS155 2.2 51.6 1.0 ND1 H:HIS147 2.4 51.5 1.0 ND1 H:HIS164 2.4 54.3 1.0 CG H:ASP167 2.8 55.9 1.0 CE1 H:HIS155 2.9 51.5 1.0 OD2 H:ASP167 3.0 56.4 1.0 CG H:HIS147 3.1 51.1 1.0 CG H:HIS164 3.2 54.6 1.0 CE1 H:HIS164 3.3 54.8 1.0 CE1 H:HIS147 3.3 51.6 1.0 CB H:HIS147 3.4 51.1 1.0 CG H:HIS155 3.4 52.3 1.0 CB H:HIS164 3.5 54.4 1.0 CB H:HIS155 4.0 52.6 1.0 NE2 H:HIS155 4.1 52.0 1.0 CD2 H:HIS164 4.2 55.2 1.0 CD2 H:HIS147 4.2 51.0 1.0 NE2 H:HIS164 4.2 55.4 1.0 CB H:ASP167 4.2 55.9 1.0 O H:ILE217 4.2 53.0 1.0 NE2 H:HIS147 4.2 51.4 1.0 CA H:HIS155 4.3 52.8 1.0 CD2 H:HIS155 4.4 52.5 1.0 CD2 H:HIS130 4.6 55.5 1.0 CA H:HIS164 4.7 55.0 1.0 CA H:ASP167 4.7 55.3 1.0 N H:HIS164 4.8 55.4 1.0 CA H:HIS147 4.9 51.0 1.0 N H:ASP167 4.9 55.1 1.0 N H:GLY156 5.0 53.5 1.0

Zinc binding site 9 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn201 b:66.3 occ:1.00 OD1 I:ASP83 1.9 72.1 1.0 ND1 I:HIS80 2.5 72.7 1.0 CD2 I:HIS71 2.6 85.7 1.0 ND1 I:HIS63 2.6 70.4 1.0 CG I:ASP83 2.7 72.3 1.0 OD2 I:ASP83 2.9 72.8 1.0 CG I:HIS80 3.2 72.8 1.0 CG I:HIS71 3.2 86.4 1.0 CE1 I:HIS80 3.3 73.9 1.0 CG I:HIS63 3.4 69.1 1.0 NE2 I:HIS71 3.4 86.2 1.0 CE1 I:HIS63 3.5 70.7 1.0 CB I:HIS63 3.6 68.3 1.0 CB I:HIS80 3.6 72.0 1.0 O I:LYS136 3.6 87.7 1.0 CB I:HIS71 3.7 85.8 1.0 CA I:HIS71 4.0 84.4 1.0 CB I:ASP83 4.1 72.3 1.0 ND1 I:HIS71 4.2 88.1 1.0 NE2 I:HIS80 4.2 74.8 1.0 CD2 I:HIS80 4.2 74.1 1.0 CE1 I:HIS71 4.2 87.4 1.0 CD2 I:HIS63 4.5 69.1 1.0 NE2 I:HIS63 4.5 69.9 1.0 CA I:ASP83 4.7 71.1 1.0 N I:HIS80 4.7 74.6 1.0 CA I:HIS80 4.7 72.6 1.0 C I:LYS136 4.8 89.2 1.0 N I:ASP83 4.8 70.2 1.0 N I:GLY72 5.0 82.9 1.0 N I:HIS71 5.0 84.4 1.0

Zinc binding site 10 out of 24 in the Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Complex of Human Cu,Zn SOD1 with the Human Copper Chaperone For SOD1 in A Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn400 b:47.4 occ:1.00 OD1 J:ASP167 1.9 50.1 1.0 ND1 J:HIS155 2.3 50.1 1.0 ND1 J:HIS147 2.4 51.6 1.0 ND1 J:HIS164 2.5 51.0 1.0 CG J:ASP167 2.7 50.3 1.0 OD2 J:ASP167 2.8 50.6 1.0 CE1 J:HIS155 3.0 50.0 1.0 CG J:HIS147 3.1 51.4 1.0 CG J:HIS164 3.3 51.0 1.0 CE1 J:HIS147 3.3 51.7 1.0 CE1 J:HIS164 3.4 51.4 1.0 CB J:HIS147 3.4 51.4 1.0 CG J:HIS155 3.5 50.6 1.0 CB J:HIS164 3.5 50.8 1.0 O J:ILE217 4.0 52.2 1.0 CB J:HIS155 4.0 50.9 1.0 CD2 J:HIS147 4.1 51.4 1.0 CB J:ASP167 4.2 50.3 1.0 NE2 J:HIS155 4.2 50.4 1.0 NE2 J:HIS147 4.2 51.6 1.0 CA J:HIS155 4.3 50.9 1.0 CD2 J:HIS164 4.3 51.4 1.0 NE2 J:HIS164 4.4 51.5 1.0 CD2 J:HIS155 4.4 50.8 1.0 CD2 J:HIS130 4.5 52.4 1.0 CA J:ASP167 4.7 50.1 1.0 CA J:HIS164 4.7 51.0 1.0 N J:ASP167 4.8 50.0 1.0 N J:HIS164 4.8 51.1 1.0 CA J:HIS147 4.9 51.4 1.0

F.A.Sala, G.S.A.Wright, S.V.Antonyuk, R.C.Garratt, S.S.Hasnain. Molecular Recognition and Maturation of SOD1 By Its Evolutionarily Destabilised Cognate Chaperone Hccs. Plos Biol. V. 17 00141 2019.
ISSN: ESSN 1545-7885
PubMed: 30735496
DOI: 10.1371/JOURNAL.PBIO.3000141