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Atomistry » Zinc » PDB 6c6t-6cee » 6cea | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 6c6t-6cee » 6cea » |
Zinc in PDB 6cea: Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger DomainEnzymatic activity of Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
All present enzymatic activity of Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain:
3.5.1.98; Protein crystallography data
The structure of Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain, PDB code: 6cea
was solved by
R.J.Harding,
L.Halabelian,
R.Ferreira De Freitas,
M.Ravichandran,
V.Santhakumar,
M.Schapira,
C.Bountra,
A.M.Edwards,
C.M.Arrowsmith,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
(pdb code 6cea). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain, PDB code: 6cea: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 6ceaGo back to Zinc Binding Sites List in 6cea
Zinc binding site 1 out
of 3 in the Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 6ceaGo back to Zinc Binding Sites List in 6cea
Zinc binding site 2 out
of 3 in the Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 6ceaGo back to Zinc Binding Sites List in 6cea
Zinc binding site 3 out
of 3 in the Crystal Structure of Fragment 3-(Quinolin-2-Yl)Propanoic Acid Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
Mono view Stereo pair view
Reference:
R.Ferreira De Freitas,
R.J.Harding,
I.Franzoni,
M.Ravichandran,
M.K.Mann,
H.Ouyang,
M.Lautens,
V.Santhakumar,
C.H.Arrowsmith,
M.Schapira.
Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem. V. 61 4517 2018.
Page generated: Mon Oct 28 18:43:48 2024
ISSN: ISSN 1520-4804 PubMed: 29741882 DOI: 10.1021/ACS.JMEDCHEM.8B00258 |
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