Atomistry » Zinc » PDB 6c6t-6cee » 6c7x
Atomistry »
  Zinc »
    PDB 6c6t-6cee »
      6c7x »

Zinc in PDB 6c7x: Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine

Enzymatic activity of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine

All present enzymatic activity of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine, PDB code: 6c7x was solved by T.S.Peat, P.Mujumdar, S.A.Poulsen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.40 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.311, 41.425, 72.424, 90.00, 104.51, 90.00
R / Rfree (%) 15.4 / 18.8

Other elements in 6c7x:

The structure of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine (pdb code 6c7x). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine, PDB code: 6c7x:

Zinc binding site 1 out of 1 in 6c7x

Go back to Zinc Binding Sites List in 6c7x
Zinc binding site 1 out of 1 in the Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase 2 in Complex with 2-Chloro-5'-O-Sulfamoyladenosine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:6.6
occ:1.00
 N13 A:EO7302 1.9 6.4 0.9
NE2 A:HIS96 2.0 6.1 1.0
NE2 A:HIS94 2.0 6.9 1.0
ND1 A:HIS119 2.0 6.1 1.0
CE1 A:HIS119 2.9 5.7 1.0
CD2 A:HIS94 3.0 7.2 1.0
CD2 A:HIS96 3.0 6.2 1.0
CE1 A:HIS96 3.0 6.3 1.0
CE1 A:HIS94 3.0 7.3 1.0
S11 A:EO7302 3.1 7.4 0.9
CG A:HIS119 3.1 5.8 1.0
O14 A:EO7302 3.2 7.8 0.9
CB A:HIS119 3.6 6.0 1.0
OG1 A:THR199 3.9 6.3 1.0
OE1 A:GLU106 4.0 6.7 1.0
NE2 A:HIS119 4.1 5.9 1.0
O12 A:EO7302 4.1 7.6 0.9
ND1 A:HIS96 4.1 6.9 1.0
CG A:HIS96 4.1 5.9 1.0
CG A:HIS94 4.1 6.9 1.0
ND1 A:HIS94 4.1 7.3 1.0
O10 A:EO7302 4.2 11.3 0.9
CD2 A:HIS119 4.2 5.8 1.0
O A:HOH651 4.3 35.3 1.0
C9 A:EO7302 4.4 12.8 0.9
CD A:GLU106 5.0 7.3 1.0

Reference:

P.Mujumdar, S.Bua, C.T.Supuran, T.S.Peat, S.A.Poulsen. Synthesis, Structure and Bioactivity of Primary Sulfamate-Containing Natural Products. Bioorg. Med. Chem. Lett. V. 28 3009 2018.
ISSN: ESSN 1464-3405
PubMed: 29685656
DOI: 10.1016/J.BMCL.2018.04.038
Page generated: Mon Oct 28 18:34:48 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy