Zinc in PDB 6c4s: Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69

All present enzymatic activity of Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69:
2.7.10.2;

The structure of Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69, PDB code: 6c4s was solved by S.L.Kall, A.Lavie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.68 / 1.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	31.117, 38.753, 57.966, 90.00, 95.70, 90.00
R / Rfree (%)	18.7 / 22.6

The binding sites of Zinc atom in the Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69 (pdb code 6c4s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69, PDB code: 6c4s:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:17.9 occ:1.00 ND1 A:HIS85 1.9 22.1 1.0 N A:HIS85 2.0 19.3 1.0 O A:HIS85 2.5 17.6 1.0 CA A:HIS85 2.8 19.6 1.0 CG A:HIS85 2.9 21.5 1.0 CE1 A:HIS85 2.9 22.3 1.0 C A:HIS85 3.1 19.6 1.0 CB A:HIS85 3.2 19.6 1.0 O A:HOH304 3.7 35.5 1.0 OG1 A:THR87 3.9 27.1 1.0 NE2 A:HIS85 4.0 26.6 1.0 CD2 A:HIS85 4.0 24.7 1.0 N A:MET86 4.4 21.7 1.0 O A:HOH351 4.7 31.2 1.0

Zinc binding site 2 out of 2 in the Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Csrc SH3 Domain in Complex with Choline Kinase Fragment 60-69 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:15.5 occ:1.00 N B:HIS85 1.8 16.2 1.0 ND1 B:HIS85 1.9 17.7 1.0 O B:HIS85 2.5 17.0 1.0 CA B:HIS85 2.8 19.0 1.0 CG B:HIS85 2.9 19.8 1.0 CE1 B:HIS85 2.9 23.8 1.0 C B:HIS85 3.0 17.6 1.0 CB B:HIS85 3.3 19.1 1.0 OG1 B:THR87 3.9 28.4 1.0 NE2 B:HIS85 4.0 26.6 1.0 CD2 B:HIS85 4.0 24.9 1.0 N B:MET86 4.3 21.3 1.0 O B:HOH329 4.5 50.6 1.0

S.L.Kall, K.Whitlatch, T.E.Smithgall, A.Lavie. Molecular Basis For the Interaction Between Human Choline Kinase Alpha and the SH3 Domain of the C-Src Tyrosine Kinase. Sci Rep V. 9 17121 2019.
ISSN: ESSN 2045-2322
PubMed: 31745227
DOI: 10.1038/S41598-019-53447-0