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Zinc in PDB 6bv1: Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid

Enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid

All present enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid:
3.4.11.2;

Protein crystallography data

The structure of Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid, PDB code: 6bv1 was solved by L.Chen, Y.-L.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.00
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 259.810, 62.682, 81.717, 90.00, 100.40, 90.00
R / Rfree (%) 20.7 / 25.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid (pdb code 6bv1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid, PDB code: 6bv1:

Zinc binding site 1 out of 1 in 6bv1

Go back to Zinc Binding Sites List in 6bv1
Zinc binding site 1 out of 1 in the Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Porcine Aminopeptidase-N with Aspartic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1035

b:27.9
occ:1.00
OE2 A:GLU406 1.9 28.0 1.0
NE2 A:HIS383 2.1 28.4 1.0
NE2 A:HIS387 2.1 26.7 1.0
O A:HOH1176 2.2 26.2 1.0
CD A:GLU406 2.7 25.5 1.0
OE1 A:GLU406 2.8 24.9 1.0
CD2 A:HIS387 2.9 26.1 1.0
CD2 A:HIS383 3.0 26.4 1.0
CE1 A:HIS383 3.2 26.4 1.0
CE1 A:HIS387 3.3 25.6 1.0
OXT A:ASP1024 3.3 30.9 1.0
C A:ASP1024 3.9 35.8 1.0
CB A:ALA409 4.1 28.3 1.0
OE1 A:GLU350 4.1 22.7 1.0
CG A:HIS387 4.1 27.7 1.0
CG A:GLU406 4.2 25.9 1.0
CG A:HIS383 4.2 28.9 1.0
OE2 A:GLU384 4.2 25.4 1.0
ND1 A:HIS383 4.2 25.9 1.0
N A:ASP1024 4.2 30.2 1.0
ND1 A:HIS387 4.3 25.9 1.0
O A:ASP1024 4.4 36.6 1.0
CE2 A:TYR472 4.5 28.0 1.0
CD A:GLU350 4.6 27.4 1.0
CA A:GLU406 4.6 26.4 1.0
CA A:ASP1024 4.6 35.4 1.0
CB A:GLU406 4.7 27.2 1.0
OE1 A:GLU384 4.7 25.7 1.0
CD A:GLU384 4.8 27.1 1.0
OE2 A:GLU350 4.8 21.5 1.0
OH A:TYR472 4.9 24.9 1.0
O A:HOH1813 5.0 33.6 1.0

Reference:

S.Joshi, L.Chen, M.B.Winter, Y.L.Lin, Y.Yang, M.Shapovalova, P.M.Smith, C.Liu, F.Li, A.M.Lebeau. The Rational Design of Therapeutic Peptides For Aminopeptidase N Using A Substrate-Based Approach. Sci Rep V. 7 1424 2017.
ISSN: ESSN 2045-2322
PubMed: 28465619
DOI: 10.1038/S41598-017-01542-5
Page generated: Wed Dec 16 11:33:22 2020

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