Zinc in PDB 6bv0: Crystal Structure of Porcine Aminopeptidase-N with Arginine

Enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Arginine

All present enzymatic activity of Crystal Structure of Porcine Aminopeptidase-N with Arginine:
3.4.11.2;

Protein crystallography data

The structure of Crystal Structure of Porcine Aminopeptidase-N with Arginine, PDB code: 6bv0 was solved by L.Chen, Y.-L.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.86
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 260.646, 62.865, 81.721, 90.00, 100.57, 90.00
R / Rfree (%) 21.5 / 26

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Porcine Aminopeptidase-N with Arginine (pdb code 6bv0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Porcine Aminopeptidase-N with Arginine, PDB code: 6bv0:

Zinc binding site 1 out of 1 in 6bv0

Go back to Zinc Binding Sites List in 6bv0
Zinc binding site 1 out of 1 in the Crystal Structure of Porcine Aminopeptidase-N with Arginine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Porcine Aminopeptidase-N with Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1035

b:25.4
occ:1.00
OE2 A:GLU406 2.0 26.8 1.0
NE2 A:HIS387 2.1 27.7 1.0
NE2 A:HIS383 2.1 27.1 1.0
O A:HOH1369 2.2 27.6 1.0
CD A:GLU406 2.8 27.3 1.0
OE1 A:GLU406 2.8 24.6 1.0
CD2 A:HIS387 3.0 26.7 1.0
CD2 A:HIS383 3.0 26.4 1.0
CE1 A:HIS383 3.1 27.0 1.0
CE1 A:HIS387 3.2 25.5 1.0
OXT A:ARG1024 3.4 33.2 1.0
N A:ARG1024 3.9 31.4 1.0
C A:ARG1024 3.9 39.1 1.0
CB A:ALA409 4.1 27.9 1.0
CG A:HIS387 4.2 27.2 1.0
CG A:HIS383 4.2 26.5 1.0
ND1 A:HIS383 4.2 27.9 1.0
ND1 A:HIS387 4.2 26.6 1.0
OE1 A:GLU350 4.2 22.1 1.0
CA A:ARG1024 4.2 34.7 1.0
CG A:GLU406 4.2 25.4 1.0
CE2 A:TYR472 4.4 28.7 1.0
OE2 A:GLU384 4.5 27.9 1.0
CA A:GLU406 4.5 26.9 1.0
CD A:GLU350 4.6 26.9 1.0
O A:ARG1024 4.7 34.9 1.0
CB A:GLU406 4.7 27.5 1.0
OE1 A:GLU384 4.7 27.1 1.0
OH A:TYR472 4.8 25.5 1.0
OE2 A:GLU350 4.9 22.9 1.0
CD A:GLU384 4.9 26.9 1.0
O A:HOH1816 5.0 37.7 1.0

Reference:

S.Joshi, L.Chen, M.B.Winter, Y.L.Lin, Y.Yang, M.Shapovalova, P.M.Smith, C.Liu, F.Li, A.M.Lebeau. The Rational Design of Therapeutic Peptides For Aminopeptidase N Using A Substrate-Based Approach. Sci Rep V. 7 1424 2017.
ISSN: ESSN 2045-2322
PubMed: 28465619
DOI: 10.1038/S41598-017-01542-5
Page generated: Wed Dec 16 11:33:20 2020

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