Zinc in PDB 5yn6: Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam

The structure of Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam, PDB code: 5yn6 was solved by S.M.Wei, L.Yang, Z.H.Ke, D.Y.Guo, C.P.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.65 / 1.95
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.962, 70.171, 119.804, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 22.7

The binding sites of Zinc atom in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam (pdb code 5yn6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam, PDB code: 5yn6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:51.7 occ:1.00 CE1 B:HIS83 1.8 53.3 1.0 SG B:CYS77 2.3 54.4 1.0 SG B:CYS74 2.3 53.0 1.0 SG B:CYS90 2.4 60.1 1.0 NE2 B:HIS83 2.4 56.1 1.0 ND1 B:HIS83 3.1 61.9 1.0 CB B:CYS74 3.2 51.9 1.0 CB B:CYS90 3.3 58.9 1.0 CB B:CYS77 3.3 54.3 1.0 N B:CYS77 3.5 51.1 1.0 CD2 B:HIS83 3.7 53.4 1.0 CA B:CYS77 3.9 52.8 1.0 CG B:HIS83 4.0 61.1 1.0 CA B:CYS90 4.4 64.3 1.0 C B:TYR76 4.5 57.2 1.0 CB B:TYR76 4.5 56.1 1.0 O B:HOH305 4.6 57.5 1.0 CA B:CYS74 4.6 52.5 1.0 CB B:LYS93 4.7 50.4 1.0 O B:CYS74 4.9 50.9 1.0 CA B:TYR76 4.9 61.2 1.0 C B:CYS74 4.9 52.4 1.0 N B:TYR76 5.0 59.3 1.0 N B:LYS93 5.0 51.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mers-Cov NSP10/NSP16 Complex Bound to Sam within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:90.9 occ:1.00 SG B:CYS120 2.3 86.3 1.0 SG B:CYS128 2.4 88.3 1.0 SG B:CYS130 2.4 95.9 1.0 SG B:CYS117 2.4 94.7 1.0 CB B:CYS120 2.9 88.9 1.0 CB B:CYS117 3.1 94.0 1.0 CB B:CYS130 3.1 99.3 1.0 CB B:CYS128 3.4 81.7 1.0 N B:CYS120 3.9 94.6 1.0 CA B:CYS120 4.0 90.3 1.0 N B:CYS130 4.0 0.2 1.0 CA B:CYS128 4.1 89.0 1.0 CA B:CYS130 4.2 0.4 1.0 C B:CYS128 4.5 91.7 1.0 N B:ASN129 4.5 93.3 1.0 CA B:CYS117 4.6 94.4 1.0 C B:CYS120 4.8 87.6 1.0

S.M.Wei, L.Yang, Z.H.Ke, Q.Y.Liu, Y.Che, Z.Z.Yang, D.Y.Guo, C.P.Fan. Structural Insights Into the Molecular Mechanism of Mers Coronavirus Rna Ribose 2'-O-Methylation By NSP16/NSP10 Protein Complex To Be Published.