Zinc in PDB 5yn5: Crystal Structure of Mers-Cov NSP10/NSP16 Complex

The structure of Crystal Structure of Mers-Cov NSP10/NSP16 Complex, PDB code: 5yn5 was solved by S.M.Wei, L.Yang, Z.H.Ke, D.Y.Guo, C.P.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.53 / 1.96
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.754, 70.527, 119.254, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 21.4

The binding sites of Zinc atom in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex (pdb code 5yn5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex, PDB code: 5yn5:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mers-Cov NSP10/NSP16 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:42.7 occ:1.00 NE2 B:HIS83 2.0 38.7 1.0 SG B:CYS77 2.3 41.6 1.0 SG B:CYS90 2.3 46.1 1.0 SG B:CYS74 2.3 41.1 1.0 CD2 B:HIS83 3.0 43.8 1.0 CE1 B:HIS83 3.0 42.8 1.0 CB B:CYS90 3.2 42.2 1.0 CB B:CYS74 3.2 39.2 1.0 CB B:CYS77 3.4 41.8 1.0 N B:CYS77 3.5 41.6 1.0 CA B:CYS77 3.9 43.6 1.0 ND1 B:HIS83 4.1 46.6 1.0 CG B:HIS83 4.1 43.2 1.0 CA B:CYS90 4.4 49.2 1.0 CB B:TYR76 4.4 45.8 1.0 C B:TYR76 4.5 43.7 1.0 CA B:CYS74 4.6 39.2 1.0 CB B:LYS93 4.7 41.5 1.0 O B:HOH327 4.7 51.8 1.0 CA B:TYR76 4.8 47.8 1.0 N B:LYS93 4.9 39.1 1.0 N B:TYR76 4.9 42.5 1.0 C B:CYS74 5.0 38.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mers-Cov NSP10/NSP16 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mers-Cov NSP10/NSP16 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:73.0 occ:1.00 CB B:CYS120 2.1 73.1 1.0 SG B:CYS128 2.3 63.8 1.0 SG B:CYS130 2.4 73.7 1.0 SG B:CYS117 2.4 71.3 1.0 SG B:CYS120 2.5 71.2 1.0 CB B:CYS130 3.0 76.6 1.0 CB B:CYS117 3.1 70.8 1.0 CB B:CYS128 3.5 66.0 1.0 CA B:CYS120 3.5 73.6 1.0 N B:CYS130 3.8 79.3 1.0 N B:CYS120 3.8 78.2 1.0 CA B:CYS130 4.0 82.3 1.0 CA B:CYS128 4.1 72.1 1.0 N B:ASN129 4.3 73.2 1.0 C B:CYS120 4.4 80.8 1.0 CG1 B:VAL119 4.5 82.6 1.0 C B:CYS128 4.5 70.1 1.0 CA B:CYS117 4.6 74.7 1.0 N B:GLN121 4.8 84.1 1.0 C B:ASN129 4.9 82.2 1.0

S.M.Wei, L.Yang, Z.H.Ke, Q.Y.Liu, Z.Z.Yang, Y.Chen, D.Y.Guo, C.P.Fan. Structural Insights Into the Molecular Mechanism of Mers Coronavirus Rna Ribose 2'-O-Methylation By NSP16/NSP10 Protein Complex To Be Published.