Zinc in PDB 5ylc: Crystal Structure of Mcr-1 Catalytic Domain

The structure of Crystal Structure of Mcr-1 Catalytic Domain, PDB code: 5ylc was solved by P.C.Wei, G.J.Song, M.Y.Shi, Y.F.Zhou, Y.Liu, J.Lei, P.Chen, L.Yin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.14 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	51.650, 72.440, 82.100, 90.00, 90.00, 90.00
R / Rfree (%)	13.6 / 18.1

The binding sites of Zinc atom in the Crystal Structure of Mcr-1 Catalytic Domain (pdb code 5ylc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Mcr-1 Catalytic Domain, PDB code: 5ylc:

Zinc binding site 1 out of 1 in the Crystal Structure of Mcr-1 Catalytic Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mcr-1 Catalytic Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:13.7 occ:0.77 OD2 A:ASP250 2.0 12.4 1.0 OE2 A:GLU31 2.1 14.9 1.0 O2P A:TPO70 2.1 13.2 1.0 NE2 A:HIS251 2.2 13.2 1.0 OE1 A:GLU31 2.2 15.3 1.0 OG1 A:TPO70 2.3 11.6 1.0 CD A:GLU31 2.5 14.2 1.0 P A:TPO70 2.9 15.7 1.0 CG A:ASP250 3.0 10.6 1.0 CE1 A:HIS251 3.0 11.8 1.0 CD2 A:HIS251 3.2 9.3 1.0 OD1 A:ASP250 3.3 10.1 1.0 CB A:TPO70 3.5 11.6 1.0 N A:TPO70 3.8 9.6 1.0 CA A:TPO70 3.8 11.6 1.0 O3P A:TPO70 3.9 14.9 1.0 NE2 A:HIS263 4.0 13.2 1.0 CG A:GLU31 4.0 11.3 1.0 O1P A:TPO70 4.0 17.8 1.0 CG2 A:TPO70 4.1 12.9 1.0 O A:HOH554 4.1 13.2 1.0 ND1 A:HIS251 4.1 9.4 1.0 OG1 A:THR32 4.2 13.3 1.0 CG A:HIS251 4.2 9.3 1.0 CB A:ASP250 4.4 9.7 1.0 C A:SER69 4.5 10.3 1.0 CD2 A:HIS180 4.6 16.4 1.0 CE1 A:HIS263 4.6 15.0 1.0 N A:THR32 4.6 10.0 1.0 CD2 A:HIS263 4.7 12.7 1.0 CA A:GLU31 4.7 11.4 1.0 NE2 A:HIS180 4.7 17.7 1.0 CB A:GLU31 4.8 10.2 1.0

P.Wei, G.Song, M.Shi, Y.Zhou, Y.Liu, J.Lei, P.Chen, L.Yin. Substrate Analog Interaction with Mcr-1 Offers Insight Into the Rising Threat of the Plasmid-Mediated Transferable Colistin Resistance. Faseb J. V. 32 1085 2018.
ISSN: ESSN 1530-6860
PubMed: 29079699
DOI: 10.1096/FJ.201700705R