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Zinc in PDB 5xil: Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs)

Enzymatic activity of Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs)

All present enzymatic activity of Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs):
6.1.1.5; 6.1.1.7;

Protein crystallography data

The structure of Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs), PDB code: 5xil was solved by V.Jain, Y.Manickam, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.99 / 1.90
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 75.294, 98.861, 146.327, 90.00, 90.00, 90.00
R / Rfree (%) 17.9 / 20.1

Other elements in 5xil:

The structure of Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs) also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs) (pdb code 5xil). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs), PDB code: 5xil:

Zinc binding site 1 out of 1 in 5xil

Go back to Zinc Binding Sites List in 5xil
Zinc binding site 1 out of 1 in the Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Leishmania Major Prolyl-Trna Synthetase (Lmprs) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:16.7
occ:1.00
 O A:ACT1002 2.1 33.7 1.0
SG A:CYS692 2.2 23.8 1.0
SG A:CYS687 2.3 23.0 1.0
SG A:CYS737 2.4 21.7 1.0
C A:ACT1002 3.0 38.6 1.0
CB A:CYS737 3.1 19.9 1.0
CH3 A:ACT1002 3.2 37.3 1.0
CB A:CYS692 3.3 19.6 1.0
CB A:CYS687 3.5 19.8 1.0
N A:CYS687 4.1 18.0 1.0
SG A:CYS739 4.1 36.2 1.0
OXT A:ACT1002 4.2 31.5 1.0
CA A:CYS687 4.4 19.7 1.0
CB A:CYS742 4.4 33.4 1.0
CA A:CYS737 4.6 19.8 1.0
O A:HOH1391 4.6 40.2 1.0
SG A:CYS742 4.6 36.4 1.0
CB A:ALA689 4.7 23.5 1.0
CA A:CYS692 4.7 21.3 1.0
CD1 A:TRP686 4.8 19.6 1.0
CB A:LYS744 4.9 34.4 1.0

Reference:

V.Jain, M.Yogavel, H.Kikuchi, Y.Oshima, N.Hariguchi, M.Matsumoto, P.Goel, B.Touquet, R.S.Jumani, F.Tacchini-Cottier, K.Harlos, C.D.Huston, M.A.Hakimi, A.Sharma. Targeting Prolyl-Trna Synthetase to Accelerate Drug Discovery Against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure V. 25 1495 2017.
ISSN: ISSN 1878-4186
PubMed: 28867614
DOI: 10.1016/J.STR.2017.07.015
Page generated: Mon Oct 28 15:01:58 2024

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