Zinc in PDB 5v3m: MOUSEZFP568-ZNF1-11 in Complex with Dna

Protein crystallography data

The structure of MOUSEZFP568-ZNF1-11 in Complex with Dna, PDB code: 5v3m was solved by A.Patel, X.Cheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.25 / 2.09
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 35.954, 92.758, 353.667, 90.00, 90.00, 90.00
R / Rfree (%) 21.3 / 25.3

Zinc Binding Sites:

The binding sites of Zinc atom in the MOUSEZFP568-ZNF1-11 in Complex with Dna (pdb code 5v3m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 10 binding sites of Zinc where determined in the MOUSEZFP568-ZNF1-11 in Complex with Dna, PDB code: 5v3m:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 1 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1001

b:76.7
occ:1.00
SG C:CYS368 2.0 84.0 1.0
NE2 C:HIS381 2.0 87.8 1.0
NE2 C:HIS385 2.0 67.9 1.0
CE1 C:HIS381 2.2 84.8 1.0
SG C:CYS365 2.4 84.5 1.0
CD2 C:HIS385 2.9 61.6 1.0
CE1 C:HIS385 3.1 58.5 1.0
CB C:CYS365 3.1 83.2 1.0
CB C:CYS368 3.3 70.7 1.0
CD2 C:HIS381 3.4 86.7 1.0
N C:CYS368 3.5 79.1 1.0
ND1 C:HIS381 3.5 87.5 1.0
CA C:CYS368 4.0 78.8 1.0
CG C:HIS385 4.0 60.4 1.0
CG C:HIS381 4.1 85.9 1.0
ND1 C:HIS385 4.1 54.4 1.0
CB C:GLU367 4.2 78.9 1.0
C C:GLU367 4.6 84.9 1.0
CA C:CYS365 4.6 88.7 1.0
CA C:GLU367 4.8 84.2 1.0
N C:GLU367 4.8 94.9 1.0
N C:GLY369 4.9 95.1 1.0
C C:CYS368 5.0 86.5 1.0

Zinc binding site 2 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 2 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1002

b:47.7
occ:1.00
NE2 C:HIS413 2.0 59.6 1.0
NE2 C:HIS409 2.1 57.2 1.0
SG C:CYS396 2.1 57.5 1.0
SG C:CYS393 2.3 43.6 1.0
CE1 C:HIS413 2.6 47.5 1.0
CD2 C:HIS409 3.0 34.0 1.0
CE1 C:HIS409 3.1 49.7 1.0
CB C:CYS396 3.2 69.3 1.0
CD2 C:HIS413 3.3 63.8 1.0
CB C:CYS393 3.3 40.9 1.0
N C:CYS396 3.6 64.0 1.0
ND1 C:HIS413 3.8 51.4 1.0
CA C:CYS396 4.0 67.4 1.0
ND1 C:HIS409 4.2 43.6 1.0
CG C:HIS413 4.2 56.2 1.0
CG C:HIS409 4.2 39.8 1.0
C C:GLU395 4.5 71.5 1.0
C C:CYS396 4.7 70.3 1.0
CB C:GLU395 4.7 77.7 1.0
CA C:CYS393 4.7 50.5 1.0
CB C:LYS398 4.8 56.8 1.0
CG1 C:VAL412 4.8 57.2 1.0
N C:GLY397 4.8 67.8 1.0
N C:GLU395 4.8 65.3 1.0
N C:LYS398 4.9 53.1 1.0
CA C:GLU395 4.9 73.3 1.0

Zinc binding site 3 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 3 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1003

b:33.1
occ:1.00
NE2 C:HIS441 1.9 18.5 1.0
NE2 C:HIS437 2.0 46.6 1.0
SG C:CYS424 2.2 38.8 1.0
SG C:CYS421 2.3 35.8 1.0
CE1 C:HIS441 2.9 31.4 1.0
CD2 C:HIS441 2.9 33.8 1.0
CD2 C:HIS437 2.9 40.6 1.0
CE1 C:HIS437 3.1 37.7 1.0
CB C:CYS421 3.2 28.9 1.0
CB C:CYS424 3.3 41.6 1.0
N C:CYS424 3.6 43.1 1.0
ND1 C:HIS441 4.0 31.9 1.0
CA C:CYS424 4.0 49.8 1.0
CG C:HIS441 4.1 31.2 1.0
CG C:HIS437 4.1 44.8 1.0
ND1 C:HIS437 4.2 36.0 1.0
O C:HOH1112 4.5 43.1 1.0
C C:GLU423 4.5 48.4 1.0
CA C:CYS421 4.6 36.9 1.0
CB C:GLU423 4.7 74.1 1.0
C C:CYS424 4.8 46.5 1.0
N C:GLY425 4.9 40.2 1.0
N C:GLU423 4.9 45.4 1.0
CA C:GLU423 4.9 42.4 1.0
O C:CYS421 5.0 42.1 1.0
C C:CYS421 5.0 45.8 1.0

Zinc binding site 4 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 4 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1004

b:61.9
occ:1.00
SG C:CYS452 1.7 44.5 1.0
NE2 C:HIS465 1.7 64.8 1.0
NE2 C:HIS469 2.3 62.7 1.0
CE1 C:HIS465 2.3 80.5 1.0
SG C:CYS449 2.4 49.7 1.0
CD2 C:HIS465 3.0 45.1 1.0
CB C:CYS452 3.1 47.7 1.0
CE1 C:HIS469 3.2 64.0 1.0
CD2 C:HIS469 3.3 59.2 1.0
CB C:CYS449 3.3 50.4 1.0
ND1 C:HIS465 3.6 63.8 1.0
N C:CYS452 3.8 78.5 1.0
CG C:HIS465 3.9 55.6 1.0
CA C:CYS452 4.0 72.8 1.0
ND1 C:HIS469 4.3 60.6 1.0
CG C:HIS469 4.4 54.4 1.0
C C:CYS452 4.6 63.7 1.0
CB C:LYS454 4.6 68.7 1.0
C C:GLU451 4.7 78.6 1.0
CA C:CYS449 4.8 58.1 1.0
CB C:GLU451 4.8 74.9 1.0
N C:GLY453 4.8 65.2 1.0
N C:LYS454 4.9 65.0 1.0
OG1 C:THR468 4.9 66.0 1.0

Zinc binding site 5 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 5 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1005

b:56.8
occ:1.00
NE2 C:HIS497 1.9 69.9 1.0
NE2 C:HIS493 2.0 68.0 1.0
SG C:CYS480 2.3 55.2 1.0
SG C:CYS477 2.3 56.8 1.0
CE1 C:HIS493 2.9 81.6 1.0
CD2 C:HIS497 2.9 56.9 1.0
CE1 C:HIS497 3.0 67.1 1.0
CD2 C:HIS493 3.1 65.4 1.0
CB C:CYS480 3.4 63.7 1.0
CB C:CYS477 3.4 53.5 1.0
N C:CYS480 3.5 67.2 1.0
CA C:CYS480 4.0 67.3 1.0
ND1 C:HIS493 4.0 67.7 1.0
ND1 C:HIS497 4.0 62.6 1.0
CG C:HIS497 4.1 68.7 1.0
CG C:HIS493 4.2 54.8 1.0
C C:ASP479 4.2 67.0 1.0
CB C:ASP479 4.3 78.3 1.0
N C:ASP479 4.5 81.4 1.0
CA C:ASP479 4.6 69.7 1.0
C C:CYS480 4.7 61.0 1.0
CA C:CYS477 4.8 59.7 1.0
O C:CYS480 4.9 71.9 1.0
CB C:LYS482 5.0 59.0 1.0

Zinc binding site 6 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 6 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1006

b:72.8
occ:1.00
CB C:CYS508 1.7 70.2 1.0
CE1 C:HIS525 2.0 79.8 1.0
NE2 C:HIS525 2.0 98.3 1.0
NE2 C:HIS521 2.1 99.4 1.0
SG C:CYS505 2.4 81.0 1.0
CE1 C:HIS521 2.8 85.9 1.0
CB C:CYS505 2.8 66.9 1.0
SG C:CYS508 2.9 75.2 1.0
CA C:CYS508 3.0 68.0 1.0
N C:CYS508 3.2 95.0 1.0
ND1 C:HIS525 3.3 93.5 1.0
CD2 C:HIS521 3.3 76.6 1.0
CD2 C:HIS525 3.4 91.9 1.0
CG C:HIS525 4.0 89.4 1.0
C C:CYS508 4.0 83.5 1.0
ND1 C:HIS521 4.0 71.0 1.0
OE1 C:GLN522 4.2 99.3 1.0
N C:GLY509 4.3 83.5 1.0
CG C:HIS521 4.3 67.1 1.0
CA C:CYS505 4.4 79.8 1.0
C C:GLU507 4.5 87.0 1.0
CB C:LYS510 4.5 75.0 1.0
N C:LYS510 4.6 70.3 1.0
O C:CYS508 4.9 87.5 1.0
CE1 C:PHE512 4.9 72.7 1.0

Zinc binding site 7 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 7 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1007

b:63.8
occ:1.00
NE2 C:HIS553 1.9 67.7 1.0
NE2 C:HIS549 2.1 71.2 1.0
SG C:CYS536 2.2 82.8 1.0
SG C:CYS533 2.4 63.2 1.0
CE1 C:HIS553 2.6 77.5 1.0
CB C:CYS536 2.7 70.9 1.0
CE1 C:HIS549 2.9 71.4 1.0
CD2 C:HIS553 3.0 60.5 1.0
N C:CYS536 3.1 68.0 1.0
CD2 C:HIS549 3.1 58.4 1.0
CB C:CYS533 3.3 63.4 1.0
CA C:CYS536 3.5 67.9 1.0
ND1 C:HIS553 3.7 70.5 1.0
CG C:HIS553 4.0 57.2 1.0
CB C:GLU535 4.0 92.8 1.0
ND1 C:HIS549 4.0 65.5 1.0
CG C:HIS549 4.2 66.5 1.0
C C:GLU535 4.2 80.8 1.0
CA C:GLU535 4.5 83.9 1.0
C C:CYS536 4.6 65.7 1.0
N C:GLY537 4.7 59.9 1.0
CA C:CYS533 4.7 61.9 1.0
N C:GLU535 4.8 86.2 1.0

Zinc binding site 8 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 8 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1008

b:79.6
occ:1.00
NE2 C:HIS577 2.0 0.3 1.0
NE2 C:HIS581 2.1 0.0 1.0
SG C:CYS564 2.1 0.1 1.0
SG C:CYS561 2.5 94.6 1.0
CE1 C:HIS577 2.6 85.7 1.0
CD2 C:HIS581 3.0 0.7 1.0
CB C:CYS564 3.0 91.3 1.0
CD2 C:HIS577 3.1 98.9 1.0
CE1 C:HIS581 3.2 0.5 1.0
N C:CYS564 3.2 89.0 1.0
CA C:CYS564 3.7 77.7 1.0
CB C:CYS561 3.7 86.4 1.0
ND1 C:HIS577 3.8 60.3 1.0
CG C:HIS577 4.0 67.1 1.0
CB C:GLU563 4.1 99.3 1.0
CG C:HIS581 4.2 0.8 1.0
ND1 C:HIS581 4.2 0.9 1.0
C C:GLU563 4.3 92.7 1.0
CA C:GLU563 4.6 0.5 1.0
N C:GLU563 4.8 0.3 1.0
C C:CYS564 4.8 87.3 1.0
CA C:GLN578 4.9 64.5 1.0
N C:GLY565 4.9 81.7 1.0

Zinc binding site 9 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 9 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1009

b:0.2
occ:1.00
NE2 C:HIS609 2.0 0.5 1.0
NE2 C:HIS605 2.1 0.6 1.0
SG C:CYS592 2.2 0.1 1.0
SG C:CYS589 2.3 0.5 1.0
CE1 C:HIS609 2.6 0.9 1.0
CE1 C:HIS605 2.9 0.5 1.0
CD2 C:HIS605 3.0 0.6 1.0
CD2 C:HIS609 3.1 0.2 1.0
CB C:CYS589 3.2 0.3 1.0
CB C:CYS592 3.5 0.3 1.0
ND1 C:HIS609 3.8 0.2 1.0
N C:CYS592 3.9 0.9 1.0
ND1 C:HIS605 3.9 0.6 1.0
CG C:HIS605 4.0 0.1 1.0
CG C:HIS609 4.1 0.4 1.0
CA C:CYS592 4.2 1.0 1.0
CA C:CYS589 4.6 0.6 1.0
CB C:GLU591 4.7 0.2 1.0
CB C:LYS594 4.7 0.4 1.0
C C:CYS592 4.7 0.8 1.0
C C:GLU591 4.9 0.0 1.0

Zinc binding site 10 out of 10 in 5v3m

Go back to Zinc Binding Sites List in 5v3m
Zinc binding site 10 out of 10 in the MOUSEZFP568-ZNF1-11 in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of MOUSEZFP568-ZNF1-11 in Complex with Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1010

b:0.8
occ:1.00
NE2 C:HIS637 2.1 0.2 1.0
SG C:CYS620 2.4 0.9 1.0
N C:CYS620 2.5 0.9 1.0
NE2 C:HIS633 2.6 0.2 1.0
SG C:CYS617 2.6 0.7 1.0
CE1 C:HIS637 2.6 0.9 1.0
CE1 C:HIS633 2.7 0.5 1.0
CB C:GLU619 2.8 0.5 1.0
CA C:CYS620 3.3 0.8 1.0
C C:GLU619 3.4 0.9 1.0
CB C:CYS620 3.4 0.9 1.0
CD2 C:HIS637 3.4 0.3 1.0
CA C:GLU619 3.5 0.7 1.0
CB C:CYS617 3.8 0.5 1.0
ND1 C:HIS637 3.9 0.3 1.0
CD2 C:HIS633 3.9 0.1 1.0
ND1 C:HIS633 4.0 0.4 1.0
N C:GLU619 4.0 0.1 1.0
CG C:HIS637 4.3 0.9 1.0
O C:GLU619 4.4 0.8 1.0
CG C:HIS633 4.6 0.2 1.0
C C:CYS620 4.7 0.2 1.0

Reference:

A.Patel, P.Yang, M.Tinkham, M.Pradhan, M.A.Sun, Y.Wang, D.Hoang, G.Wolf, J.R.Horton, X.Zhang, T.Macfarlan, X.Cheng. Dna Conformation Induces Adaptable Binding By Tandem Zinc Finger Proteins. Cell V. 173 221 2018.
ISSN: ISSN 1097-4172
PubMed: 29551271
DOI: 10.1016/J.CELL.2018.02.058
Page generated: Wed Dec 16 11:07:43 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy