Zinc in PDB 5uiw: Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5

The structure of Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5, PDB code: 5uiw was solved by Y.Zheng, L.Qin, G.W.Han, M.Gustavsson, T.Kawamura, R.C.Stevens, V.Cherezov, I.Kufareva, T.M.Handel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.47 / 2.20
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	38.010, 52.640, 302.670, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 25

The binding sites of Zinc atom in the Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5 (pdb code 5uiw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5, PDB code: 5uiw:

Zinc binding site 1 out of 1 in the Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Cc Chemokine Receptor 5 (CCR5) in Complex with High Potency Hiv Entry Inhibitor 5P7-CCL5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:35.3 occ:0.85 SG A:CYS1009 2.2 30.2 1.0 SG A:CYS1039 2.3 33.4 1.0 SG A:CYS1042 2.3 47.4 1.0 SG A:CYS1006 2.5 32.6 1.0 CB A:CYS1009 3.0 37.8 1.0 CB A:CYS1006 3.3 33.5 1.0 CB A:CYS1039 3.3 35.0 1.0 CB A:CYS1042 3.4 33.4 1.0 N A:CYS1009 3.7 43.5 1.0 N A:CYS1042 3.8 33.3 1.0 CA A:CYS1009 3.9 38.3 1.0 CA A:CYS1042 4.1 33.4 1.0 CG2 A:VAL1044 4.4 47.8 1.0 CB A:TYR1011 4.5 34.9 1.0 N A:GLY1010 4.5 36.6 1.0 C A:CYS1009 4.5 38.2 1.0 CB A:VAL1008 4.5 50.0 1.0 CB A:LEU1041 4.6 30.9 1.0 CA A:CYS1006 4.7 43.4 1.0 CA A:CYS1039 4.7 36.6 1.0 C A:VAL1008 4.7 44.8 1.0 C A:LEU1041 4.8 33.3 1.0 N A:GLY1043 4.8 42.5 1.0 N A:TYR1011 4.8 37.5 1.0 C A:CYS1042 4.8 40.1 1.0

Y.Zheng, G.W.Han, R.Abagyan, B.Wu, R.C.Stevens, V.Cherezov, I.Kufareva, T.M.Handel. Structure of Cc Chemokine Receptor 5 with A Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry By Hiv. Immunity V. 46 1005 2017.
ISSN: ISSN 1097-4180
PubMed: 28636951
DOI: 10.1016/J.IMMUNI.2017.05.002