Atomistry » Zinc » PDB 5uck-5ulh » 5uhd
Atomistry »
  Zinc »
    PDB 5uck-5ulh »
      5uhd »

Zinc in PDB 5uhd: Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin

Enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin

All present enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin:
2.7.7.6;

Protein crystallography data

The structure of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin, PDB code: 5uhd was solved by W.Lin, K.Das, Y.Feng, R.H.Ebright, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.48 / 4.01
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 152.079, 163.099, 197.904, 90.00, 90.00, 90.00
R / Rfree (%) 21.1 / 26.4

Other elements in 5uhd:

The structure of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin (pdb code 5uhd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin, PDB code: 5uhd:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5uhd

Go back to Zinc Binding Sites List in 5uhd
Zinc binding site 1 out of 2 in the Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1401

b:32.5
occ:1.00
CB D:CYS968 2.2 45.6 1.0
SG D:CYS975 2.2 44.1 1.0
SG D:CYS968 2.3 47.1 1.0
SG D:CYS978 2.3 84.4 1.0
SG D:CYS891 2.3 49.3 1.0
CB D:CYS891 2.8 57.2 1.0
CB D:CYS975 3.4 44.9 1.0
CA D:CYS968 3.5 49.0 1.0
CB D:CYS978 3.6 49.0 1.0
N D:CYS891 3.8 52.8 1.0
C D:CYS968 3.8 39.6 1.0
CA D:CYS891 3.9 53.8 1.0
O D:CYS968 4.1 33.6 1.0
N D:CYS975 4.2 36.2 1.0
OG1 D:THR970 4.3 46.6 1.0
CA D:CYS975 4.3 35.9 1.0
NH2 D:ARG963 4.4 60.3 1.0
N D:CYS978 4.5 43.9 1.0
N D:ALA969 4.5 40.1 1.0
N D:CYS968 4.7 51.7 1.0
CA D:CYS978 4.7 45.0 1.0
NE D:ARG963 4.8 65.5 1.0
C D:CYS975 4.8 34.9 1.0
C D:ASP890 4.9 46.8 1.0
C D:CYS891 5.0 53.2 1.0

Zinc binding site 2 out of 2 in 5uhd

Go back to Zinc Binding Sites List in 5uhd
Zinc binding site 2 out of 2 in the Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mycobacterium Tuberculosis Transcription Initiation Complex Containing 4NT Rna in Complex with Rifampin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1402

b:44.7
occ:1.00
SG D:CYS60 2.2 37.5 1.0
SG D:CYS62 2.2 55.1 1.0
SG D:CYS75 2.3 27.5 1.0
SG D:CYS78 2.5 56.3 1.0
CB D:CYS62 3.1 46.9 1.0
N D:CYS62 3.3 45.5 1.0
CB D:CYS75 3.5 29.5 1.0
CA D:CYS62 3.7 52.4 1.0
CB D:CYS60 3.9 35.2 1.0
N D:GLY63 4.1 53.5 1.0
CB D:LYS64 4.1 47.8 1.0
C D:CYS62 4.2 57.3 1.0
CB D:CYS78 4.2 39.7 1.0
N D:LYS64 4.2 46.7 1.0
N D:CYS78 4.2 47.9 1.0
CB D:ARG77 4.3 49.6 1.0
N D:TYR61 4.3 36.4 1.0
C D:TYR61 4.5 42.3 1.0
C D:CYS60 4.6 36.0 1.0
CA D:CYS78 4.7 41.4 1.0
C D:ARG77 4.7 46.3 1.0
CA D:LYS64 4.8 48.7 1.0
CD2 D:TYR65 4.8 49.2 1.0
N D:ARG77 4.8 33.8 1.0
CA D:ARG77 4.9 40.6 1.0
CA D:TYR61 4.9 38.2 1.0
CA D:CYS60 4.9 34.7 1.0
CA D:CYS75 4.9 37.0 1.0

Reference:

W.Lin, S.Mandal, D.Degen, Y.Liu, Y.W.Ebright, S.Li, Y.Feng, Y.Zhang, S.Mandal, Y.Jiang, S.Liu, M.Gigliotti, M.Talaue, N.Connell, K.Das, E.Arnold, R.H.Ebright. Structural Basis of Mycobacterium Tuberculosis Transcription and Transcription Inhibition. Mol. Cell V. 66 169 2017.
ISSN: ISSN 1097-4164
PubMed: 28392175
DOI: 10.1016/J.MOLCEL.2017.03.001
Page generated: Mon Oct 28 09:33:42 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy