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Atomistry » Zinc » PDB 5u0d-5ubi » 5u7l | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5u0d-5ubi » 5u7l » |
Zinc in PDB 5u7l: PDE2 Catalytic Domain Complexed with InhibitorsEnzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors
All present enzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors:
3.1.4.17; Protein crystallography data
The structure of PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7l
was solved by
J.Pandit,
K.Parris,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5u7l:
The structure of PDE2 Catalytic Domain Complexed with Inhibitors also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the PDE2 Catalytic Domain Complexed with Inhibitors
(pdb code 5u7l). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7l: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 5u7lGo back to Zinc Binding Sites List in 5u7l
Zinc binding site 1 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 5u7lGo back to Zinc Binding Sites List in 5u7l
Zinc binding site 2 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 5u7lGo back to Zinc Binding Sites List in 5u7l
Zinc binding site 3 out
of 3 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Reference:
C.J.Helal,
E.P.Arnold,
T.L.Boyden,
C.Chang,
T.A.Chappie,
K.F.Fennell,
M.D.Forman,
M.Hajos,
J.F.Harms,
W.E.Hoffman,
J.M.Humphrey,
Z.Kang,
R.J.Kleiman,
B.L.Kormos,
C.W.Lee,
J.Lu,
N.Maklad,
L.Mcdowell,
S.Mente,
R.E.O'connor,
J.Pandit,
M.Piotrowski,
A.W.Schmidt,
C.J.Schmidt,
H.Ueno,
P.R.Verhoest,
E.X.Yang.
Application of Structure-Based Design and Parallel Chemistry to Identify A Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J. Med. Chem. V. 60 5673 2017.
Page generated: Mon Oct 28 09:09:30 2024
ISSN: ISSN 1520-4804 PubMed: 28574706 DOI: 10.1021/ACS.JMEDCHEM.7B00397 |
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