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Zinc in PDB 5t1a: Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Enzymatic activity of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

All present enzymatic activity of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists:
3.2.1.17;

Protein crystallography data

The structure of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists, PDB code: 5t1a was solved by Y.Zheng, L.Qin, N.V.Ortiz Zacarias, H.De Vries, G.W.Han, M.Gustavsson, M.Dabros, C.Zhao, R.J.Cherney, P.Carter, D.Stamos, R.Abagyan, V.Cherezov, R.C.Stevens, A.P.Ijzerman, L.H.Heitman, A.Tebben, I.Kufareva, T.M.Handel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.32 / 2.81
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.230, 64.690, 169.980, 90.00, 90.00, 90.00
R / Rfree (%) 23.4 / 27.4

Other elements in 5t1a:

The structure of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists (pdb code 5t1a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists, PDB code: 5t1a:

Zinc binding site 1 out of 1 in 5t1a

Go back to Zinc Binding Sites List in 5t1a
Zinc binding site 1 out of 1 in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1208

b:40.3
occ:1.00
 OE2 A:GLU238 1.9 48.8 1.0
O A:HOH1307 2.0 7.8 1.0
OE2 A:GLU1005 2.0 43.8 1.0
NE2 A:HIS144 2.0 26.5 1.0
CD A:GLU238 2.8 48.6 1.0
CD A:GLU1005 2.9 40.8 1.0
CE1 A:HIS144 3.0 32.0 1.0
CD2 A:HIS144 3.0 26.2 1.0
OE1 A:GLU238 3.1 52.2 1.0
OE1 A:GLU1005 3.2 44.2 1.0
O A:ILE142 4.0 31.4 1.0
ND1 A:HIS144 4.1 31.9 1.0
CG A:PRO235 4.1 34.4 1.0
CG A:HIS144 4.1 30.8 1.0
O A:ARG232 4.1 45.1 1.0
CG A:GLU238 4.2 45.3 1.0
CG A:GLU1005 4.2 36.0 1.0
CB A:PRO235 4.3 33.8 1.0
CB A:GLU238 4.6 40.9 1.0
C A:ILE142 4.6 30.0 1.0
CA A:ILE142 4.7 28.6 1.0
CB A:ASN1002 4.8 41.2 1.0
CG1 A:ILE142 4.8 27.5 1.0
O A:ALA141 4.8 30.3 1.0
CD2 A:PHE1004 5.0 25.4 1.0

Reference:

Y.Zheng, L.Qin, N.V.Zacarias, H.De Vries, G.W.Han, M.Gustavsson, M.Dabros, C.Zhao, R.J.Cherney, P.Carter, D.Stamos, R.Abagyan, V.Cherezov, R.C.Stevens, A.P.Ijzerman, L.H.Heitman, A.Tebben, I.Kufareva, T.M.Handel. Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists. Nature V. 540 458 2016.
ISSN: ESSN 1476-4687
PubMed: 27926736
DOI: 10.1038/NATURE20605
Page generated: Mon Oct 28 08:14:28 2024

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