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Atomistry » Zinc » PDB 5sgt-5shw » 5sh3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5sgt-5shw » 5sh3 » |
Zinc in PDB 5sh3: Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]PyridazineEnzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
All present enzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine:
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine, PDB code: 5sh3
was solved by
C.Joseph,
J.Benz,
A.Flohr,
K.Groebke-Zbinden,
M.G.Rudolph,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5sh3:
The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
(pdb code 5sh3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine, PDB code: 5sh3: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 5sh3Go back to Zinc Binding Sites List in 5sh3
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 5sh3Go back to Zinc Binding Sites List in 5sh3
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 5sh3Go back to Zinc Binding Sites List in 5sh3
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 5sh3Go back to Zinc Binding Sites List in 5sh3
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 2,3- Dimethyl-6-[2-(2-Methyl-5-Pyrrolidin-1-Yl-1,2,4-Triazol-3-Yl)Ethyl]- 8-Methylsulfonylimidazo[1,2-B]Pyridazine
Mono view Stereo pair view
Reference:
A.Flohr,
D.Schlatter,
B.Kuhn,
M.G.Rudolph.
Crystal Structure of A Human Phosphodiesterase 10 Complex To Be Published.
Page generated: Fri Apr 7 22:19:07 2023
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