Atomistry » Zinc » PDB 5lsx-5m2h » 5lt6
Atomistry »
  Zinc »
    PDB 5lsx-5m2h »
      5lt6 »

Zinc in PDB 5lt6: Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives

Enzymatic activity of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives

All present enzymatic activity of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives:
2.1.1.43;

Protein crystallography data

The structure of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives, PDB code: 5lt6 was solved by D.Tisi, P.Pathuri, T.Heightman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 61.86 / 2.05
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 57.360, 72.700, 61.860, 90.00, 89.77, 90.00
R / Rfree (%) 17.9 / 23.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives (pdb code 5lt6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives, PDB code: 5lt6:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6;

Zinc binding site 1 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 1 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1801

b:42.3
occ:1.00
 SG A:CYS1631 2.2 44.6 1.0
SG A:CYS1678 2.3 44.0 1.0
SG A:CYS1680 2.4 36.6 1.0
SG A:CYS1685 2.4 50.8 1.0
CB A:CYS1685 3.2 47.9 1.0
CB A:CYS1680 3.4 32.7 1.0
CB A:CYS1678 3.4 43.4 1.0
CB A:CYS1631 3.4 39.6 1.0
CA A:CYS1685 3.6 47.4 1.0
N A:CYS1631 4.0 35.3 1.0
N A:ARG1686 4.0 51.8 1.0
O A:HOH1979 4.0 42.1 1.0
N A:CYS1680 4.1 35.8 1.0
CA A:CYS1680 4.2 35.5 1.0
C A:CYS1685 4.3 55.2 1.0
CA A:CYS1631 4.3 38.6 1.0
NE2 A:HIS1629 4.4 35.5 1.0
CD2 A:HIS1629 4.5 35.9 1.0
O A:CYS1678 4.5 44.0 1.0
C A:CYS1678 4.6 45.6 1.0
CA A:CYS1678 4.6 44.8 1.0
N A:GLY1687 4.6 56.3 1.0
H64 A:76J1805 4.6 34.2 1.0
N A:GLY1681 4.8 41.3 1.0
N A:CYS1685 4.8 46.4 1.0
C A:CYS1680 4.9 43.4 1.0
C A:SER1630 4.9 34.6 1.0

Zinc binding site 2 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 2 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1802

b:52.1
occ:1.00
 SG A:CYS1516 2.2 56.5 1.0
SG A:CYS1539 2.4 52.4 1.0
SG A:CYS1529 2.5 50.4 1.0
SG A:CYS1533 2.5 70.6 1.0
CB A:CYS1516 3.1 51.1 1.0
CB A:CYS1529 3.1 46.6 1.0
CB A:CYS1539 3.4 49.7 1.0
CB A:CYS1533 3.7 66.8 1.0
ZN A:ZN1803 3.9 51.9 1.0
S A:SCN1804 4.1 75.0 1.0
SG A:CYS1499 4.3 66.3 1.0
CB A:ASN1541 4.4 40.1 1.0
CA A:CYS1539 4.4 50.0 1.0
CA A:CYS1516 4.5 52.2 1.0
CA A:CYS1529 4.6 45.9 1.0
SG A:CYS1520 4.7 52.0 1.0
CB A:ASN1535 4.7 65.7 1.0
N A:ASN1541 5.0 45.0 1.0
CA A:CYS1533 5.0 69.3 1.0
ND2 A:ASN1541 5.0 39.7 1.0

Zinc binding site 3 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 3 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1803

b:51.9
occ:1.00
 SG A:CYS1520 2.2 52.0 1.0
SG A:CYS1499 2.4 66.3 1.0
SG A:CYS1501 2.4 63.8 1.0
SG A:CYS1516 2.6 56.5 1.0
CB A:CYS1499 3.0 62.2 1.0
CB A:CYS1520 3.1 48.2 1.0
CB A:CYS1501 3.1 62.9 1.0
CB A:CYS1516 3.3 51.1 1.0
CA A:CYS1516 3.7 52.2 1.0
CA A:CYS1520 3.8 49.2 1.0
ZN A:ZN1802 3.9 52.1 1.0
O B:HOH1929 4.0 45.6 1.0
SG A:CYS1529 4.2 50.4 1.0
CA A:CYS1501 4.3 65.4 1.0
N A:CYS1501 4.4 65.0 1.0
CA A:CYS1499 4.5 63.8 1.0
N A:CYS1516 4.6 53.8 1.0
C A:CYS1520 4.7 53.3 1.0
N A:LEU1521 4.7 53.1 1.0
C A:CYS1516 4.8 55.6 1.0
N A:CYS1520 4.9 52.1 1.0
O A:HOH1923 5.0 71.9 1.0
C A:CYS1499 5.0 66.8 1.0

Zinc binding site 4 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 4 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1801

b:52.0
occ:1.00
 SG B:CYS1520 2.3 49.9 1.0
SG B:CYS1499 2.3 67.7 1.0
SG B:CYS1501 2.5 65.2 1.0
SG B:CYS1516 2.5 57.0 1.0
CB B:CYS1499 3.0 63.7 1.0
CB B:CYS1501 3.1 63.3 1.0
CB B:CYS1520 3.2 47.5 1.0
CB B:CYS1516 3.3 52.6 1.0
CA B:CYS1516 3.7 55.4 1.0
CA B:CYS1520 3.8 49.7 1.0
ZN B:ZN1802 3.9 54.3 1.0
O B:HOH1953 4.0 46.5 1.0
SG B:CYS1529 4.2 51.3 1.0
CA B:CYS1501 4.3 65.2 1.0
N B:CYS1501 4.3 64.2 1.0
CA B:CYS1499 4.5 65.9 1.0
N B:CYS1516 4.5 59.6 1.0
S B:SCN1804 4.6 67.7 1.0
C B:CYS1520 4.7 54.7 1.0
C B:CYS1516 4.8 59.9 1.0
N B:LEU1521 4.8 53.2 1.0
C B:CYS1499 5.0 69.6 1.0
N B:CYS1520 5.0 51.5 1.0
ND2 B:ASN1535 5.0 72.0 1.0

Zinc binding site 5 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 5 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1802

b:54.3
occ:1.00
 SG B:CYS1516 2.1 57.0 1.0
SG B:CYS1539 2.4 50.8 1.0
SG B:CYS1529 2.4 51.3 1.0
SG B:CYS1533 2.5 69.4 1.0
CB B:CYS1529 3.1 48.1 1.0
CB B:CYS1516 3.2 52.6 1.0
CB B:CYS1539 3.5 50.4 1.0
CB B:CYS1533 3.7 66.1 1.0
S B:SCN1804 3.7 67.7 1.0
ZN B:ZN1801 3.9 52.0 1.0
SG B:CYS1499 4.2 67.7 1.0
CB B:ASN1541 4.4 47.4 1.0
CA B:CYS1539 4.5 52.4 1.0
CA B:CYS1529 4.6 47.4 1.0
CA B:CYS1516 4.6 55.4 1.0
SG B:CYS1520 4.7 49.9 1.0
CB B:ASN1535 4.7 64.5 1.0
CA B:CYS1533 5.0 69.0 1.0
ND2 B:ASN1541 5.0 33.7 1.0
N B:ASN1541 5.0 49.4 1.0

Zinc binding site 6 out of 6 in 5lt6

Go back to Zinc Binding Sites List in 5lt6
Zinc binding site 6 out of 6 in the Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1803

b:65.0
occ:1.00
 SG B:CYS1678 2.2 70.2 1.0
SG B:CYS1631 2.4 63.0 1.0
SG B:CYS1680 2.5 73.8 1.0
SG B:CYS1685 2.8 80.7 1.0
CB B:CYS1678 3.3 69.3 1.0
CB B:CYS1680 3.3 67.5 1.0
CB B:CYS1631 3.5 59.2 1.0
CB B:CYS1685 3.6 77.9 1.0
CA B:CYS1685 3.6 76.6 1.0
N B:ARG1686 4.0 76.2 1.0
N B:CYS1631 4.0 56.1 1.0
N B:CYS1680 4.1 68.9 1.0
O B:CYS1678 4.2 75.5 1.0
C B:CYS1685 4.3 80.1 1.0
CA B:CYS1680 4.3 67.7 1.0
CA B:CYS1631 4.3 57.7 1.0
C B:CYS1678 4.3 74.7 1.0
CD2 B:HIS1629 4.4 52.3 1.0
CA B:CYS1678 4.4 70.5 1.0
NE2 B:HIS1629 4.5 52.9 1.0
N B:GLY1687 4.8 80.4 1.0
H64 B:76J1805 4.8 46.4 0.8
OG B:SER1682 4.8 84.9 1.0
N B:CYS1685 4.8 77.8 1.0
C B:SER1630 4.9 57.6 1.0

Reference:

D.Tisi, E.Chiarparin, E.Tamanini, P.Pathuri, J.E.Coyle, A.Hold, F.P.Holding, N.Amin, A.C.Martin, S.J.Rich, V.Berdini, J.Yon, P.Acklam, R.Burke, L.Drouin, J.E.Harmer, F.Jeganathan, R.L.Van Montfort, Y.Newbatt, M.Tortorici, M.Westlake, A.Wood, S.Hoelder, T.D.Heightman. Structure of the Epigenetic Oncogene Mmset and Inhibition By N-Alkyl Sinefungin Derivatives. Acs Chem. Biol. V. 11 3093 2016.
ISSN: ESSN 1554-8937
PubMed: 27571355
DOI: 10.1021/ACSCHEMBIO.6B00308
Page generated: Sun Oct 27 21:27:19 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy