Zinc in PDB 5lkz: Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.

Enzymatic activity of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.

All present enzymatic activity of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A., PDB code: 5lkz was solved by Z.Kaczmarska, E.Ortega, J.A.Marquez, D.Panne, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 93.600, 155.910, 110.090, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 23.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A. (pdb code 5lkz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A., PDB code: 5lkz:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 5lkz

Go back to Zinc Binding Sites List in 5lkz
Zinc binding site 1 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1701

b:96.6
occ:1.00
SG A:CYS1201 2.3 76.8 1.0
SG A:CYS1204 2.4 85.0 1.0
SG A:CYS1183 2.4 93.8 1.0
SG A:CYS1177 2.4 95.8 1.0
CB A:CYS1201 3.4 84.5 1.0
CB A:CYS1177 3.4 95.1 1.0
CB A:CYS1204 3.6 88.1 1.0
CB A:CYS1183 3.6 96.0 1.0
O A:GLY1179 3.9 0.6 1.0
N A:CYS1201 4.1 86.7 1.0
CA A:CYS1201 4.3 85.2 1.0
CA A:CYS1177 4.9 97.5 1.0
CA A:CYS1204 4.9 90.2 1.0
O A:CYS1201 4.9 83.6 1.0
CA A:CYS1183 5.0 0.8 1.0

Zinc binding site 2 out of 4 in 5lkz

Go back to Zinc Binding Sites List in 5lkz
Zinc binding site 2 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1702

b:53.3
occ:1.00
SG A:CYS1250 2.3 50.5 1.0
SG A:CYS1247 2.3 48.5 1.0
SG A:CYS1272 2.3 53.7 1.0
SG A:CYS1275 2.3 59.4 1.0
CB A:CYS1247 3.2 49.0 1.0
CB A:CYS1250 3.3 54.5 1.0
CB A:CYS1272 3.4 54.2 1.0
CB A:CYS1275 3.4 62.1 1.0
N A:CYS1250 3.8 55.4 1.0
N A:CYS1272 4.0 48.8 1.0
CA A:CYS1250 4.1 53.8 1.0
N A:CYS1275 4.2 61.0 1.0
CA A:CYS1272 4.2 52.9 1.0
CA A:CYS1275 4.4 64.2 1.0
CA A:CYS1247 4.7 47.7 1.0
O A:CYS1272 4.8 57.4 1.0
C A:CYS1272 4.8 55.8 1.0
CB A:GLU1249 4.9 61.2 1.0
C A:CYS1250 4.9 53.0 1.0
C A:GLU1249 4.9 58.8 1.0

Zinc binding site 3 out of 4 in 5lkz

Go back to Zinc Binding Sites List in 5lkz
Zinc binding site 3 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1703

b:37.6
occ:1.00
ND1 A:HIS1255 2.1 37.2 1.0
SG A:CYS1164 2.3 41.1 1.0
SG A:CYS1163 2.3 38.8 1.0
SG A:CYS1258 2.4 35.9 1.0
CE1 A:HIS1255 3.0 38.4 1.0
CG A:HIS1255 3.1 36.4 1.0
CB A:CYS1163 3.4 43.9 1.0
CB A:HIS1255 3.4 36.8 1.0
CB A:CYS1258 3.4 34.6 1.0
CB A:CYS1164 3.5 40.4 1.0
N A:CYS1164 3.6 42.7 1.0
C A:CYS1163 4.0 45.0 1.0
CA A:CYS1164 4.0 41.4 1.0
N A:HIS1255 4.2 38.7 1.0
NE2 A:HIS1255 4.2 37.8 1.0
CD2 A:HIS1255 4.2 36.7 1.0
CA A:CYS1163 4.3 45.6 1.0
O A:CYS1164 4.3 42.4 1.0
CA A:HIS1255 4.4 37.3 1.0
C A:CYS1164 4.4 42.2 1.0
NH2 A:ARG1166 4.5 45.8 1.0
CD1 A:LEU1168 4.6 36.8 1.0
O A:CYS1163 4.7 48.8 1.0
CA A:CYS1258 4.9 35.5 1.0
NH2 A:ARG1645 4.9 30.6 1.0

Zinc binding site 4 out of 4 in 5lkz

Go back to Zinc Binding Sites List in 5lkz
Zinc binding site 4 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Crotonyl-Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1704

b:27.9
occ:0.50
NE2 A:HIS1315 2.2 27.8 1.0
SG A:CYS1408 2.3 27.2 0.5
SG A:CYS1408 2.4 27.2 0.5
CD2 A:HIS1315 3.1 28.8 1.0
CE1 A:HIS1315 3.2 27.9 1.0
CB A:CYS1408 3.3 26.5 0.5
CB A:CYS1408 3.4 26.4 0.5
ND1 A:HIS1315 4.3 29.6 1.0
CG A:HIS1315 4.3 30.1 1.0
CA A:CYS1408 4.7 26.5 0.5
CA A:CYS1408 4.8 26.4 0.5

Reference:

Z.Kaczmarska, E.Ortega, A.Goudarzi, H.Huang, S.Kim, J.A.Marquez, Y.Zhao, S.Khochbin, D.Panne. Structure of P300 in Complex with Acyl-Coa Variants. Nat. Chem. Biol. V. 13 21 2017.
ISSN: ESSN 1552-4469
PubMed: 27820805
DOI: 10.1038/NCHEMBIO.2217
Page generated: Wed Dec 16 06:29:32 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy