Atomistry » Zinc » PDB 5lku-5lrj » 5lku
Atomistry »
  Zinc »
    PDB 5lku-5lrj »
      5lku »

Zinc in PDB 5lku: Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.

Enzymatic activity of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.

All present enzymatic activity of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A., PDB code: 5lku was solved by Z.Kaczmarska, E.Ortega, J.A.Marquez, D.Panne, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.01 / 3.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 93.960, 156.400, 110.680, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 24.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A. (pdb code 5lku). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A., PDB code: 5lku:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 5lku

Go back to Zinc Binding Sites List in 5lku
Zinc binding site 1 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1701

b:0.7
occ:1.00
SG A:CYS1183 2.1 89.3 1.0
SG A:CYS1204 2.2 0.8 1.0
SG A:CYS1201 2.4 75.9 1.0
SG A:CYS1177 2.7 0.9 1.0
CB A:CYS1183 3.1 98.8 1.0
CB A:CYS1204 3.3 0.7 1.0
CB A:CYS1177 3.5 0.2 1.0
CB A:CYS1201 3.6 88.6 1.0
N A:CYS1201 4.3 0.2 1.0
CA A:CYS1183 4.5 0.9 1.0
CA A:CYS1201 4.5 93.6 1.0
CA A:CYS1204 4.6 0.6 1.0
N A:CYS1204 4.7 0.7 1.0
CD A:LYS1180 4.9 0.9 1.0
C A:CYS1183 4.9 0.8 1.0
NZ A:LYS1180 5.0 97.5 1.0

Zinc binding site 2 out of 4 in 5lku

Go back to Zinc Binding Sites List in 5lku
Zinc binding site 2 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1702

b:70.9
occ:1.00
SG A:CYS1275 2.1 71.6 1.0
SG A:CYS1250 2.2 54.2 1.0
SG A:CYS1247 2.3 58.8 1.0
SG A:CYS1272 2.6 63.4 1.0
CB A:CYS1250 3.1 56.4 1.0
CB A:CYS1247 3.3 62.8 1.0
CB A:CYS1275 3.3 76.9 1.0
N A:CYS1250 3.5 65.7 1.0
CB A:CYS1272 3.6 70.3 1.0
CA A:CYS1250 3.9 59.4 1.0
N A:CYS1272 4.1 64.5 1.0
N A:CYS1275 4.2 76.0 1.0
CA A:CYS1275 4.3 78.9 1.0
CA A:CYS1272 4.4 69.5 1.0
CB A:GLU1249 4.6 76.3 1.0
C A:GLU1249 4.6 70.7 1.0
CA A:CYS1247 4.7 64.4 1.0
C A:CYS1250 4.8 59.5 1.0
O A:CYS1272 4.9 74.0 1.0
N A:GLY1251 4.9 60.0 1.0
CA A:GLU1249 4.9 73.4 1.0
NH1 A:ARG1252 4.9 69.5 1.0
C A:CYS1272 5.0 73.4 1.0
N A:GLU1249 5.0 75.7 1.0

Zinc binding site 3 out of 4 in 5lku

Go back to Zinc Binding Sites List in 5lku
Zinc binding site 3 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1703

b:59.5
occ:1.00
ND1 A:HIS1255 2.1 49.4 1.0
SG A:CYS1163 2.1 46.4 1.0
SG A:CYS1164 2.1 47.1 1.0
SG A:CYS1258 2.6 48.3 1.0
CE1 A:HIS1255 3.1 50.6 1.0
CG A:HIS1255 3.1 50.4 1.0
CB A:CYS1163 3.3 50.7 1.0
CB A:HIS1255 3.4 52.6 1.0
CB A:CYS1164 3.4 48.1 1.0
CB A:CYS1258 3.5 46.0 1.0
N A:CYS1164 3.5 49.4 1.0
C A:CYS1163 4.0 53.8 1.0
CA A:CYS1164 4.0 47.7 1.0
N A:HIS1255 4.1 52.0 1.0
NE2 A:HIS1255 4.2 52.1 1.0
CD2 A:HIS1255 4.2 51.1 1.0
CA A:CYS1163 4.2 53.3 1.0
O A:CYS1164 4.3 45.5 1.0
CA A:HIS1255 4.4 50.7 1.0
C A:CYS1164 4.4 48.0 1.0
O A:CYS1163 4.6 59.0 1.0
CA A:CYS1258 5.0 46.1 1.0
N A:CYS1163 5.0 54.5 1.0

Zinc binding site 4 out of 4 in 5lku

Go back to Zinc Binding Sites List in 5lku
Zinc binding site 4 out of 4 in the Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the P300 Acetyltransferase Catalytic Core with Coenzyme A. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1704

b:95.7
occ:1.00
SG A:CYS1408 2.4 56.5 1.0
NE2 A:HIS1315 2.4 39.5 1.0
CD2 A:HIS1315 3.1 38.5 1.0
CE1 A:HIS1315 3.5 42.1 1.0
CB A:CYS1408 3.8 49.2 1.0
CG A:HIS1315 4.4 39.4 1.0
ND1 A:HIS1315 4.5 41.6 1.0
CA A:CYS1408 4.9 48.5 1.0
N A:CYS1408 5.0 44.6 1.0

Reference:

Z.Kaczmarska, E.Ortega, A.Goudarzi, H.Huang, S.Kim, J.A.Marquez, Y.Zhao, S.Khochbin, D.Panne. Structure of P300 in Complex with Acyl-Coa Variants. Nat. Chem. Biol. V. 13 21 2017.
ISSN: ESSN 1552-4469
PubMed: 27820805
DOI: 10.1038/NCHEMBIO.2217
Page generated: Wed Dec 16 06:29:31 2020

Last articles

Zn in 7M6U
Zn in 7NNG
Zn in 7NEE
Zn in 7NEU
Zn in 7M3K
Zn in 7KWD
Zn in 7KYH
Zn in 7KNG
Zn in 7KY2
Zn in 7KYF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy