Atomistry » Zinc » PDB 5jn3-5k1a » 5jt5
Atomistry »
  Zinc »
    PDB 5jn3-5k1a »
      5jt5 »

Zinc in PDB 5jt5: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide, PDB code: 5jt5 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.80 / 1.21
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.293, 65.276, 70.641, 90.00, 96.12, 90.00
R / Rfree (%) 13.5 / 15.7

Other elements in 5jt5:

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide (pdb code 5jt5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide, PDB code: 5jt5:

Zinc binding site 1 out of 1 in 5jt5

Go back to Zinc Binding Sites List in 5jt5
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:11.9
occ:1.00
 ND1 A:HIS349 2.1 11.5 1.0
SG A:CYS320 2.3 11.5 1.0
SG A:CYS323 2.3 12.6 1.0
SG A:CYS318 2.3 13.6 1.0
CE1 A:HIS349 2.9 12.2 1.0
CG A:HIS349 3.2 10.6 1.0
CB A:CYS323 3.3 12.2 1.0
CB A:CYS318 3.3 14.7 1.0
CB A:CYS320 3.4 12.3 1.0
CB A:HIS349 3.7 10.7 1.0
N A:CYS323 3.9 12.0 1.0
CA A:HIS349 4.1 10.6 1.0
NE2 A:HIS349 4.1 12.3 1.0
N A:CYS320 4.1 14.3 1.0
CA A:CYS323 4.2 12.4 1.0
CA A:CYS320 4.2 13.0 1.0
CD2 A:HIS349 4.3 11.6 1.0
O A:HIS349 4.5 10.7 1.0
CA A:CYS318 4.6 15.3 1.0
O A:CYS320 4.7 12.8 1.0
C A:CYS320 4.7 12.1 1.0
C A:CYS318 4.7 15.5 1.0
C A:HIS349 4.8 10.2 1.0
CB A:VAL322 4.8 11.8 1.0
O A:CYS318 4.8 16.2 1.0
C A:VAL322 4.9 11.6 1.0

Reference:

F.R.Ehrmann, C.Hohn, A.Heine, F.Diederich, G.Klebe. Benzimidazole-Based Inhibitors As A Novel Scaffold to Inhibit Z.Mobilis Tgt and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of Lin-Benzopurines. To Be Published.
Page generated: Sun Oct 27 19:13:26 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy