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Zinc in PDB 5jsv: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One
Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One:
2.4.2.29;
2.4.2.29;
Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One, PDB code: 5jsv
was solved by
F.R.Ehrmann,
D.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 39.95 / 1.17 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.505, 65.200, 70.598, 90.00, 96.44, 90.00 |
| R / Rfree (%) | 12.1 / 13.9 |
Other elements in 5jsv:
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One
(pdb code 5jsv). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One, PDB code: 5jsv:
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One, PDB code: 5jsv:
Zinc binding site 1 out of 1 in 5jsv
Go back to
Zinc Binding Sites List in 5jsv
Zinc binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One within 5.0Å range:
|
Reference:
F.R.Ehrmann,
E.Schaefer,
A.Heine,
F.Diederich,
G.Klebe.
Application of Carbohydrates Based Lin-Benzoguanines in A Solvent-Exposed Subpocket of the Trna-Modifying Enzyme Tgt To Be Published.
Page generated: Sun Oct 27 19:13:26 2024
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