Atomistry » Zinc » PDB 5hou-5i3a » 5i00
Atomistry »
  Zinc »
    PDB 5hou-5i3a »
      5i00 »

Zinc in PDB 5i00: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 5i00 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.11 / 1.49
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.299, 65.114, 70.644, 90.00, 96.25, 90.00
R / Rfree (%) 12.5 / 15.6

Other elements in 5i00:

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One (pdb code 5i00). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 5i00:

Zinc binding site 1 out of 1 in 5i00

Go back to Zinc Binding Sites List in 5i00
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-{2-[(Cyclopentylmethyl)Amino]Ethyl}-2-(Methylamino)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:12.8
occ:1.00
 ND1 A:HIS349 2.1 11.4 1.0
SG A:CYS320 2.3 12.3 1.0
SG A:CYS318 2.3 13.7 1.0
SG A:CYS323 2.3 12.7 1.0
CE1 A:HIS349 2.9 11.8 1.0
CG A:HIS349 3.3 10.4 1.0
CB A:CYS318 3.3 14.7 1.0
CB A:CYS323 3.3 12.3 1.0
CB A:CYS320 3.4 11.3 1.0
CB A:HIS349 3.7 10.8 1.0
N A:CYS323 3.9 12.0 1.0
NE2 A:HIS349 4.1 11.8 1.0
CA A:HIS349 4.1 10.6 1.0
N A:CYS320 4.1 12.8 1.0
CA A:CYS323 4.2 13.1 1.0
CA A:CYS320 4.2 12.2 1.0
CD2 A:HIS349 4.3 11.8 1.0
O A:HIS349 4.6 11.1 1.0
CA A:CYS318 4.6 14.7 1.0
O A:CYS320 4.6 13.3 1.0
C A:CYS320 4.7 12.7 1.0
C A:CYS318 4.7 15.3 1.0
CB A:VAL322 4.8 12.0 1.0
C A:HIS349 4.8 10.8 1.0
O A:CYS318 4.8 16.1 1.0
C A:VAL322 4.9 12.8 1.0

Reference:

F.R.Ehrmann, J.Stojko, K.Reuter, A.Heine, G.Klebe, S.Sanglier-Cianferani, F.Diederich. Co-Crystallization, Isothermal Titration Calorimetry and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors To Be Published.
Page generated: Sun Oct 27 17:44:01 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy