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Zinc in PDB 5hmz: Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23Enzymatic activity of Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23
All present enzymatic activity of Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23:
2.7.7.48; Protein crystallography data
The structure of Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23, PDB code: 5hmz
was solved by
C.G.Noble,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23
(pdb code 5hmz). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23, PDB code: 5hmz: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5hmzGo back to Zinc Binding Sites List in 5hmz
Zinc binding site 1 out
of 2 in the Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 5hmzGo back to Zinc Binding Sites List in 5hmz
Zinc binding site 2 out
of 2 in the Dengue Serotype 3 Rna-Dependent Rna Polymerase Bound to Compound 23
Mono view Stereo pair view
Reference:
F.Yokokawa,
S.Nilar,
C.G.Noble,
S.P.Lim,
R.Rao,
S.Tania,
G.Wang,
G.Lee,
J.Hunziker,
R.Karuna,
U.Manjunatha,
P.Y.Shi,
P.W.Smith.
Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral Rna-Dependent Rna Polymerase From A Fragment Hit Using Structure-Based Drug Design J.Med.Chem. V. 59 3935 2016.
Page generated: Wed Dec 16 06:20:34 2020
ISSN: ISSN 0022-2623 PubMed: 26984786 DOI: 10.1021/ACS.JMEDCHEM.6B00143 |
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