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Zinc in PDB 5fp3: Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine DemethylasesProtein crystallography data
The structure of Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases, PDB code: 5fp3
was solved by
C.Chung,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5fp3:
The structure of Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases
(pdb code 5fp3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases, PDB code: 5fp3: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5fp3Go back to Zinc Binding Sites List in 5fp3
Zinc binding site 1 out
of 2 in the Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 5fp3Go back to Zinc Binding Sites List in 5fp3
Zinc binding site 2 out
of 2 in the Cell Penetrant Inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) Families of Histone Lysine Demethylases
Mono view Stereo pair view
Reference:
S.M.Westaway,
A.G.S.Preston,
M.D.Barker,
F.Brown,
J.A.Brown,
M.Campbell,
C.Chung,
H.Diallo,
C.Douault,
G.Drewes,
R.Eagle,
L.Gordon,
C.Haslam,
T.G.Hayhow,
P.G.Humphreys,
G.Joberty,
R.Katso,
L.Kruidenier,
M.Leveridge,
J.Liddle,
J.Mosley,
M.Muelbaier,
R.Randle,
I.Rioja,
A.Rueger,
G.A.Seal,
R.J.Sheppard,
O.Singh,
J.Taylor,
P.Thomas,
D.Thomson,
D.M.Wilson,
K.Lee,
R.K.Prinjha.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. J.Med.Chem. V. 59 1357 2016.
Page generated: Wed Dec 16 06:15:34 2020
ISSN: ISSN 0022-2623 PubMed: 26771107 DOI: 10.1021/ACS.JMEDCHEM.5B01537 |
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