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Zinc in PDB 5fl5: Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- SulfonamideEnzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
All present enzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide:
4.2.1.1; Protein crystallography data
The structure of Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide, PDB code: 5fl5
was solved by
J.Leitans,
K.Tars,
R.Zalubovskis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
(pdb code 5fl5). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide, PDB code: 5fl5: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 5fl5Go back to Zinc Binding Sites List in 5fl5
Zinc binding site 1 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 5fl5Go back to Zinc Binding Sites List in 5fl5
Zinc binding site 2 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 5fl5Go back to Zinc Binding Sites List in 5fl5
Zinc binding site 3 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 5fl5Go back to Zinc Binding Sites List in 5fl5
Zinc binding site 4 out
of 4 in the Three Dimensional Structure of Human Carbonic Anhydrase IX in Complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-Triazol-4-Yl)Thiophene-2- Sulfonamide
Mono view Stereo pair view
Reference:
J.Leitans,
A.Kazaks,
A.Balode,
J.Ivanova,
R.Zalubovskis,
C.T.Supuran,
K.Tars.
An Efficient Expression and Crystallization System of the Cancer Asociated Carbonic Anhydrase Isoform IX. J.Med.Chem. V. 58 9004 2015.
Page generated: Sun Oct 27 16:16:42 2024
ISSN: ISSN 0022-2623 PubMed: 26522624 DOI: 10.1021/ACS.JMEDCHEM.5B01343 |
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