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Zinc in PDB 5acu: Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
Enzymatic activity of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
All present enzymatic activity of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening:
3.5.2.6;
3.5.2.6;
Protein crystallography data
The structure of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening, PDB code: 5acu
was solved by
T.Christopeit,
T.J.O.Carlsen,
R.Helland,
H.K.S.Leiros,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 24.957 / 2.10 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 64.422, 75.795, 79.292, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 25.59 / 28.69 |
Other elements in 5acu:
The structure of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
(pdb code 5acu). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening, PDB code: 5acu:
Jump to Zinc binding site number: 1; 2; 3;
In total 3 binding sites of Zinc where determined in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening, PDB code: 5acu:
Jump to Zinc binding site number: 1; 2; 3;
Zinc binding site 1 out of 3 in 5acu
Go back to
Zinc Binding Sites List in 5acu
Zinc binding site 1 out
of 3 in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening within 5.0Å range:
|
Zinc binding site 2 out of 3 in 5acu
Go back to
Zinc Binding Sites List in 5acu
Zinc binding site 2 out
of 3 in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening within 5.0Å range:
|
Zinc binding site 3 out of 3 in 5acu
Go back to
Zinc Binding Sites List in 5acu
Zinc binding site 3 out
of 3 in the Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Vim-2-Nat, Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening within 5.0Å range:
|
Reference:
T.Christopeit,
T.J.O.Carlsen,
R.Helland,
H.K.S.Leiros.
Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 By Spr Based Fragment Screening J.Med.Chem. V. 58 8671 2015.
ISSN: ISSN 0022-2623
PubMed: 26477515
DOI: 10.1021/ACS.JMEDCHEM.5B01289
Page generated: Sun Oct 27 12:49:22 2024
ISSN: ISSN 0022-2623
PubMed: 26477515
DOI: 10.1021/ACS.JMEDCHEM.5B01289
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