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Zinc in PDB 4ywp: Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX

Enzymatic activity of Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX

All present enzymatic activity of Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX:
4.2.1.1;

Protein crystallography data

The structure of Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX, PDB code: 4ywp was solved by M.A.Pinard, M.Aggarwal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.45
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 41.845, 41.240, 72.275, 90.00, 103.76, 90.00
R / Rfree (%) 16.2 / 19

Zinc Binding Sites:

The binding sites of Zinc atom in the Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX (pdb code 4ywp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX, PDB code: 4ywp:

Zinc binding site 1 out of 1 in 4ywp

Go back to Zinc Binding Sites List in 4ywp
Zinc binding site 1 out of 1 in the Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sucrose Binding Site in Genetically Engineered Carbonic Anhydrase IX within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:3.7
occ:1.00
O A:HOH491 1.9 4.5 1.0
ND1 A:HIS119 2.0 2.2 1.0
NE2 A:HIS94 2.0 2.9 1.0
NE2 A:HIS96 2.1 4.5 1.0
CE1 A:HIS119 2.9 2.3 1.0
CD2 A:HIS94 3.0 4.2 1.0
HE1 A:HIS119 3.0 2.8 1.0
CE1 A:HIS96 3.0 4.2 1.0
CE1 A:HIS94 3.1 3.3 1.0
CD2 A:HIS96 3.1 3.6 1.0
HD2 A:HIS94 3.1 5.1 1.0
CG A:HIS119 3.1 2.8 1.0
HE1 A:HIS96 3.2 5.0 1.0
HB2 A:HIS119 3.2 3.8 1.0
HD2 A:HIS96 3.3 4.3 1.0
HE1 A:HIS94 3.3 4.0 1.0
HG1 A:THR199 3.5 3.7 1.0
CB A:HIS119 3.6 3.1 1.0
O A:HOH434 3.6 5.9 1.0
HB3 A:HIS119 3.8 3.8 1.0
OG1 A:THR199 3.8 3.1 1.0
OE1 A:GLU106 4.0 3.8 1.0
NE2 A:HIS119 4.1 4.1 1.0
O A:HOH595 4.1 7.8 1.0
CG A:HIS94 4.1 3.3 1.0
ND1 A:HIS96 4.1 3.8 1.0
ND1 A:HIS94 4.1 4.0 1.0
CD2 A:HIS119 4.2 5.0 1.0
CG A:HIS96 4.2 3.2 1.0
O A:HOH637 4.2 9.8 1.0
HH2 A:TRP209 4.3 5.0 1.0
O A:HOH589 4.6 12.4 1.0
HE2 A:HIS119 4.8 4.9 1.0
HG23 A:THR200 4.8 5.6 1.0
CD A:GLU106 4.8 4.5 1.0
HD1 A:HIS96 4.9 4.6 1.0
HD1 A:HIS94 4.9 4.8 1.0

Reference:

M.A.Pinard, M.Aggarwal, B.P.Mahon, C.Tu, R.Mckenna. A Sucrose-Binding Site Provides A Lead Towards An Isoform-Specific Inhibitor of the Cancer-Associated Enzyme Carbonic Anhydrase IX. Acta Crystallogr F Struct V. 71 1352 2015BIOL Commun.
ISSN: ESSN 2053-230X
PubMed: 26457530
DOI: 10.1107/S2053230X1501239X
Page generated: Wed Dec 16 05:58:18 2020

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