Atomistry » Zinc » PDB 4yiw-4yye » 4yo8
Atomistry »
  Zinc »
    PDB 4yiw-4yye »
      4yo8 »

Zinc in PDB 4yo8: Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol

Enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol

All present enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol:
3.2.2.30; 3.2.2.9;

Protein crystallography data

The structure of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8 was solved by S.A.Cameron, S.Wang, S.C.Almo, V.L.Schramm, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 65.091, 69.446, 65.566, 90.00, 113.08, 90.00
R / Rfree (%) 18.7 / 22.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol (pdb code 4yo8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8:

Zinc binding site 1 out of 1 in 4yo8

Go back to Zinc Binding Sites List in 4yo8
Zinc binding site 1 out of 1 in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:45.1
occ:1.00
OE2 A:GLU211 1.9 39.2 1.0
CD A:GLU211 2.7 37.3 1.0
OE1 A:GLU211 2.8 37.9 1.0
CG A:GLU211 4.2 37.0 1.0

Reference:

S.Wang, S.A.Cameron, K.Clinch, G.B.Evans, Z.Wu, V.L.Schramm, P.C.Tyler. New Antibiotic Candidates Against Helicobacter Pylori. J.Am.Chem.Soc. V. 137 14275 2015.
ISSN: ESSN 1520-5126
PubMed: 26494017
DOI: 10.1021/JACS.5B06110
Page generated: Wed Dec 16 05:58:00 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy