Atomistry » Zinc » PDB 4ylp-4z0q » 4yo8
Atomistry »
  Zinc »
    PDB 4ylp-4z0q »
      4yo8 »

Zinc in PDB 4yo8: Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol

Enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol

All present enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol:
3.2.2.30; 3.2.2.9;

Protein crystallography data

The structure of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8 was solved by S.A.Cameron, S.Wang, S.C.Almo, V.L.Schramm, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 65.091, 69.446, 65.566, 90.00, 113.08, 90.00
R / Rfree (%) 18.7 / 22.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol (pdb code 4yo8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8:

Zinc binding site 1 out of 1 in 4yo8

Go back to Zinc Binding Sites List in 4yo8
Zinc binding site 1 out of 1 in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:45.1
occ:1.00
OE2 A:GLU211 1.9 39.2 1.0
CD A:GLU211 2.7 37.3 1.0
OE1 A:GLU211 2.8 37.9 1.0
CG A:GLU211 4.2 37.0 1.0

Reference:

S.Wang, S.A.Cameron, K.Clinch, G.B.Evans, Z.Wu, V.L.Schramm, P.C.Tyler. New Antibiotic Candidates Against Helicobacter Pylori. J.Am.Chem.Soc. V. 137 14275 2015.
ISSN: ESSN 1520-5126
PubMed: 26494017
DOI: 10.1021/JACS.5B06110
Page generated: Sun Oct 27 11:19:51 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy