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Atomistry » Zinc » PDB 4ura-4uxy » 4ux4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4ura-4uxy » 4ux4 » |
Zinc in PDB 4ux4: Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-IumEnzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium
All present enzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium:
2.4.2.30; Protein crystallography data
The structure of Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium, PDB code: 4ux4
was solved by
T.Haikarainen,
L.Lehtio,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium
(pdb code 4ux4). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium, PDB code: 4ux4: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4ux4Go back to Zinc Binding Sites List in 4ux4
Zinc binding site 1 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4ux4Go back to Zinc Binding Sites List in 4ux4
Zinc binding site 2 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 1-Methyl-7-(4- Methylphenyl)-5-Oxo-5,6-Dihydro-1,6-Naphthyridin-1-Ium
Mono view Stereo pair view
Reference:
K.Kumpan,
A.Nathubhai,
C.Zhang,
P.J.Wood,
M.D.Lloyd,
A.S.Thompson,
T.Haikarainen,
L.Lehtio,
M.D.Threadgill.
Structure-Based Design, Synthesis and Evaluation in Vitro of Arylnaphthyridinones, Arylpyridopyrimidinones and Their Tetrahydro Derivatives As Inhibitors of the Tankyrases. Bioorg.Med.Chem. V. 23 3013 2015.
Page generated: Wed Dec 16 05:49:38 2020
ISSN: ISSN 0968-0896 PubMed: 26026769 DOI: 10.1016/J.BMC.2015.05.005 |
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