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Atomistry » Zinc » PDB 4ura-4uxy » 4uvy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4ura-4uxy » 4uvy » |
Zinc in PDB 4uvy: Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-OneEnzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One
All present enzymatic activity of Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One:
2.4.2.30; Protein crystallography data
The structure of Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One, PDB code: 4uvy
was solved by
T.Haikarainen,
M.Narwal,
L.Lehtio,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uvy:
The structure of Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One
(pdb code 4uvy). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One, PDB code: 4uvy: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4uvyGo back to Zinc Binding Sites List in 4uvy
Zinc binding site 1 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4uvyGo back to Zinc Binding Sites List in 4uvy
Zinc binding site 2 out
of 2 in the Crystal Structure of Human Tankyrase 2 in Complex with 3-(4- Chlorophenyl)-5-Methoxy-1,2- Dihydroisoquinolin-1-One
Mono view Stereo pair view
Reference:
H.A.Paine,
A.Nathubhai,
E.C.Y.Woon,
P.T.Sunderland,
P.J.Wood,
M.F.Mahon,
M.D.Lloyd,
A.S.Thompson,
T.Haikarainen,
M.Narwal,
L.Lehtio,
M.D.Threadgill.
Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones As Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem. V. 23 5891 2015.
Page generated: Sun Oct 27 09:21:32 2024
ISSN: ISSN 0968-0896 PubMed: 26189030 DOI: 10.1016/J.BMC.2015.06.061 |
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