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Zinc in PDB 4uov: The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.

Enzymatic activity of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.

All present enzymatic activity of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.:
4.2.1.1;

Protein crystallography data

The structure of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability., PDB code: 4uov was solved by P.James, M.Isupov, C.Sayer, S.Berg, M.Lioliou, H.Kotlar, J.Littlechild, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.01 / 1.85
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 163.750, 283.020, 52.170, 90.00, 90.00, 90.00
R / Rfree (%) 17.181 / 20.404

Other elements in 4uov:

The structure of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. also contains other interesting chemical elements:

Chlorine (Cl) 15 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. (pdb code 4uov). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability., PDB code: 4uov:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6;

Zinc binding site 1 out of 6 in 4uov

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Zinc binding site 1 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn298

b:19.4
occ:1.00
 N1 A:AZM299 2.0 21.6 1.0
NE2 A:HIS114 2.1 18.7 1.0
NE2 A:HIS112 2.1 19.4 1.0
ND1 A:HIS131 2.1 14.7 1.0
CD2 A:HIS112 3.0 18.6 1.0
CE1 A:HIS131 3.0 14.1 1.0
CE1 A:HIS114 3.0 20.7 1.0
CD2 A:HIS114 3.1 16.6 1.0
O2 A:AZM299 3.1 21.5 1.0
S1 A:AZM299 3.1 23.4 1.0
CE1 A:HIS112 3.1 19.8 1.0
CG A:HIS131 3.2 14.6 1.0
CB A:HIS131 3.6 14.1 1.0
OE1 A:GLU118 3.8 19.1 1.0
OG1 A:THR198 4.0 17.2 1.0
NE2 A:HIS131 4.1 15.7 1.0
CG A:HIS112 4.1 19.3 1.0
ND1 A:HIS114 4.2 18.0 1.0
C1 A:AZM299 4.2 28.6 1.0
ND1 A:HIS112 4.2 19.2 1.0
CG A:HIS114 4.2 18.0 1.0
O1 A:AZM299 4.2 23.6 1.0
CD2 A:HIS131 4.2 13.2 1.0
CD A:GLU118 4.8 20.0 1.0
N3 A:AZM299 4.8 31.1 1.0

Zinc binding site 2 out of 6 in 4uov

Go back to Zinc Binding Sites List in 4uov
Zinc binding site 2 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn298

b:17.4
occ:1.00
 N1 B:AZM299 1.9 19.5 1.0
ND1 B:HIS131 2.1 13.8 1.0
NE2 B:HIS114 2.1 15.1 1.0
NE2 B:HIS112 2.1 18.2 1.0
CE1 B:HIS131 2.9 14.7 1.0
CD2 B:HIS114 3.0 15.8 1.0
CD2 B:HIS112 3.0 19.1 1.0
O2 B:AZM299 3.1 17.9 1.0
S1 B:AZM299 3.1 21.2 1.0
CE1 B:HIS112 3.1 19.7 1.0
CE1 B:HIS114 3.1 17.7 1.0
CG B:HIS131 3.2 12.2 1.0
CB B:HIS131 3.6 13.1 1.0
OE1 B:GLU118 3.8 17.9 1.0
OG1 B:THR198 4.0 18.0 1.0
NE2 B:HIS131 4.1 12.8 1.0
O1 B:AZM299 4.1 22.0 1.0
C1 B:AZM299 4.2 29.1 1.0
CG B:HIS114 4.2 13.5 1.0
CG B:HIS112 4.2 17.3 1.0
ND1 B:HIS114 4.2 16.1 1.0
ND1 B:HIS112 4.2 17.2 1.0
CD2 B:HIS131 4.2 13.5 1.0
CD B:GLU118 4.8 18.0 1.0
N3 B:AZM299 4.9 33.6 1.0

Zinc binding site 3 out of 6 in 4uov

Go back to Zinc Binding Sites List in 4uov
Zinc binding site 3 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn298

b:20.3
occ:1.00
 N1 C:AZM299 2.0 21.8 1.0
NE2 C:HIS112 2.0 21.6 1.0
ND1 C:HIS131 2.1 16.4 1.0
NE2 C:HIS114 2.1 20.3 1.0
CE1 C:HIS131 2.9 14.9 1.0
CD2 C:HIS112 3.0 20.5 1.0
CD2 C:HIS114 3.0 19.5 1.0
O2 C:AZM299 3.1 17.7 1.0
CE1 C:HIS112 3.1 21.0 1.0
S1 C:AZM299 3.1 23.0 1.0
CG C:HIS131 3.2 15.3 1.0
CE1 C:HIS114 3.2 19.4 1.0
O C:HOH2162 3.5 47.1 1.0
CB C:HIS131 3.6 15.4 1.0
OE1 C:GLU118 3.8 21.2 1.0
OG1 C:THR198 4.0 17.3 1.0
NE2 C:HIS131 4.1 16.3 1.0
CG C:HIS112 4.1 20.4 1.0
ND1 C:HIS112 4.1 20.9 1.0
C1 C:AZM299 4.1 25.5 1.0
O1 C:AZM299 4.2 23.8 1.0
CG C:HIS114 4.2 18.8 1.0
CD2 C:HIS131 4.2 15.4 1.0
ND1 C:HIS114 4.2 20.6 1.0
CD C:GLU118 4.8 19.5 1.0
N3 C:AZM299 4.8 28.4 1.0

Zinc binding site 4 out of 6 in 4uov

Go back to Zinc Binding Sites List in 4uov
Zinc binding site 4 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn298

b:20.1
occ:1.00
 N1 D:AZM299 2.0 24.0 1.0
NE2 D:HIS112 2.1 19.8 1.0
ND1 D:HIS131 2.1 17.8 1.0
NE2 D:HIS114 2.1 17.1 1.0
CD2 D:HIS112 2.9 22.4 1.0
CE1 D:HIS131 3.0 16.8 1.0
CD2 D:HIS114 3.0 16.9 1.0
O2 D:AZM299 3.0 18.7 1.0
S1 D:AZM299 3.1 25.8 1.0
CE1 D:HIS114 3.1 19.4 1.0
CE1 D:HIS112 3.2 24.4 1.0
CG D:HIS131 3.2 15.6 1.0
O D:HOH2119 3.5 52.1 1.0
CB D:HIS131 3.6 16.6 1.0
OE1 D:GLU118 3.9 20.7 1.0
OG1 D:THR198 4.1 19.8 1.0
CG D:HIS112 4.1 25.6 1.0
NE2 D:HIS131 4.1 16.2 1.0
C1 D:AZM299 4.2 28.3 1.0
CG D:HIS114 4.2 19.5 1.0
O1 D:AZM299 4.2 25.7 1.0
ND1 D:HIS112 4.2 21.4 1.0
ND1 D:HIS114 4.2 17.3 1.0
CD2 D:HIS131 4.2 15.4 1.0
N3 D:AZM299 4.8 32.7 1.0
CD D:GLU118 4.8 20.5 1.0

Zinc binding site 5 out of 6 in 4uov

Go back to Zinc Binding Sites List in 4uov
Zinc binding site 5 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn298

b:18.8
occ:1.00
 N1 E:AZM299 1.9 21.7 1.0
NE2 E:HIS112 2.0 16.7 1.0
NE2 E:HIS114 2.1 18.7 1.0
ND1 E:HIS131 2.1 14.8 1.0
CD2 E:HIS112 2.9 18.4 1.0
CE1 E:HIS131 3.0 14.2 1.0
O2 E:AZM299 3.0 18.3 1.0
CD2 E:HIS114 3.0 18.9 1.0
S1 E:AZM299 3.1 22.3 1.0
CE1 E:HIS112 3.1 17.6 1.0
CE1 E:HIS114 3.1 18.4 1.0
CG E:HIS131 3.2 14.3 1.0
CB E:HIS131 3.6 14.7 1.0
OE1 E:GLU118 3.9 19.6 1.0
OG1 E:THR198 4.0 18.7 1.0
CG E:HIS112 4.1 16.8 1.0
C1 E:AZM299 4.1 25.7 1.0
ND1 E:HIS112 4.1 17.9 1.0
O1 E:AZM299 4.2 24.7 1.0
NE2 E:HIS131 4.2 14.4 1.0
CG E:HIS114 4.2 17.6 1.0
ND1 E:HIS114 4.2 18.9 1.0
CD2 E:HIS131 4.3 13.3 1.0
N3 E:AZM299 4.8 30.6 1.0
CD E:GLU118 4.8 22.3 1.0

Zinc binding site 6 out of 6 in 4uov

Go back to Zinc Binding Sites List in 4uov
Zinc binding site 6 out of 6 in the The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of The Structure of A Tetrameric Alpha-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides, Which Contribute to Its Thermostability. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn298

b:17.1
occ:1.00
 N1 F:AZM299 1.9 19.6 1.0
ND1 F:HIS131 2.0 13.4 1.0
NE2 F:HIS112 2.1 15.5 1.0
NE2 F:HIS114 2.1 12.7 1.0
CE1 F:HIS131 2.9 14.1 1.0
CD2 F:HIS112 3.0 16.8 1.0
S1 F:AZM299 3.0 19.7 1.0
CD2 F:HIS114 3.1 15.7 1.0
O2 F:AZM299 3.1 18.4 1.0
CE1 F:HIS112 3.1 17.5 1.0
CE1 F:HIS114 3.1 16.0 1.0
CG F:HIS131 3.2 14.8 1.0
CB F:HIS131 3.6 11.4 1.0
OE1 F:GLU118 3.8 19.9 1.0
OG1 F:THR198 4.0 16.6 1.0
NE2 F:HIS131 4.1 14.2 1.0
C1 F:AZM299 4.1 25.2 1.0
O1 F:AZM299 4.2 17.8 1.0
CG F:HIS112 4.2 15.6 1.0
ND1 F:HIS112 4.2 15.5 1.0
CG F:HIS114 4.2 13.2 1.0
ND1 F:HIS114 4.2 12.8 1.0
CD2 F:HIS131 4.2 12.8 1.0
N3 F:AZM299 4.8 25.3 1.0
CD F:GLU118 4.9 18.3 1.0

Reference:

P.James, M.N.Isupov, C.Sayer, V.Saneei, S.Berg, M.Lioliou, H.Kotlar, J.Littlechild. The Structure of A Tetrameric [Alpha]-Carbonic Anhydrase From Thermovibrio Ammonificans Reveals A Core Formed Around Intermolecular Disulfides That Contribute to Its Thermostability Acta Crystallogr.,Sect.D V. 70 2607 2014.
ISSN: ISSN 0907-4449
PubMed: 25286845
DOI: 10.1107/S1399004714016526
Page generated: Wed Dec 16 05:48:59 2020

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