Zinc in PDB 4tz4: Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide

The structure of Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide, PDB code: 4tz4 was solved by P.P.Chamberlain, B.Pagarigan, S.Delker, B.Leon, M.Riley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 3.01
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	71.862, 129.117, 198.677, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 27.1

The binding sites of Zinc atom in the Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide (pdb code 4tz4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide, PDB code: 4tz4:

Zinc binding site 1 out of 1 in the Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn501 b:45.5 occ:1.00 SG C:CYS391 2.1 46.3 1.0 SG C:CYS394 2.3 44.4 1.0 SG C:CYS323 2.3 48.4 1.0 SG C:CYS326 2.4 67.8 1.0 CB C:CYS391 3.1 44.9 1.0 CB C:CYS394 3.2 48.0 1.0 CB C:CYS323 3.2 49.9 1.0 CB C:CYS326 3.4 68.3 1.0 N C:CYS394 3.6 48.9 1.0 N C:CYS326 3.9 62.6 1.0 CA C:CYS394 3.9 48.9 1.0 CA C:CYS326 4.2 66.0 1.0 CB C:ILE393 4.4 49.2 1.0 CA C:CYS391 4.5 44.2 1.0 C C:ILE393 4.7 49.7 1.0 CA C:CYS323 4.7 49.6 1.0 CB C:GLN325 4.8 56.5 1.0 C C:CYS394 4.8 48.6 1.0 N C:ILE393 4.9 48.3 1.0 CA C:ILE393 4.9 49.5 1.0 C C:CYS391 4.9 45.7 1.0 O C:CYS391 5.0 46.6 1.0 C C:GLN325 5.0 60.4 1.0 OG C:SER396 5.0 44.4 1.0 N C:ALA395 5.0 47.9 1.0

P.P.Chamberlain, M.Wang, M.Riley, S.Delker, G.Carmel, K.Miller, A.Lopez-Girona, B.Pagarigan, B.Leon, E.Rychak, L.Corral, A.Lopez-Girona, Y.Ren, M.Wang, M.Riley, S.Delker, T.Ito, A.Hideki, T.Mori, H.Handa, T.Hakoshima, T.O.Daniel, K.Miller, B.E.Cathers, G.Carmel, B.Pagarigan, B.Leon, E.Rychak, L.Corral, Y.Ren. Structural Basis For Responsiveness to Thalidomide-Analog Drugs Defined By the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex To Be Published.